BBA

Baker Bros. Advisors Portfolio holdings

AUM $10.3B
This Quarter Return
-6.2%
1 Year Return
+63.34%
3 Year Return
+231.6%
5 Year Return
+293.68%
10 Year Return
+1,612.7%
AUM
$20.6B
AUM Growth
+$20.6B
Cap. Flow
+$41.1M
Cap. Flow %
0.2%
Top 10 Hldgs %
83.49%
Holding
127
New
5
Increased
17
Reduced
8
Closed
5

Top Buys

1
INCY icon
Incyte
INCY
$117M
2
TRDA icon
Entrada Therapeutics
TRDA
$80.5M
3
CCXI
ChemoCentryx, Inc.
CCXI
$48.4M
4
TSVT
2seventy bio
TSVT
$21.4M
5
TVTX icon
Travere Therapeutics
TVTX
$19.5M

Top Sells

1
SGEN
Seagen Inc. Common Stock
SGEN
$61.1M
2
FLGT icon
Fulgent Genetics
FLGT
$20.1M
3
BLUE
bluebird bio
BLUE
$13.6M
4
MIRM icon
Mirum Pharmaceuticals
MIRM
$12.9M
5
AUPH icon
Aurinia Pharmaceuticals
AUPH
$11.5M

Sector Composition

1 Healthcare 98.2%
Name Market Value Portfolio Weight Shares or Principal Shares
Change % 		Capital Flow
NRIX icon
26
Nurix Therapeutics
NRIX
$723M
$71M 0.35%
2,454,082
– –
TIL icon
27
Instil Bio
TIL
$196M
$66.6M 0.32%
194,685
– –
MRUS icon
28
Merus
MRUS
$5.04B
$64.8M 0.32%
2,037,469
– –
HZNP
29
DELISTED
Horizon Therapeutics Public Limited Company Ordinary Shares
HZNP
$64.6M 0.31%
599,110
– –
IMTX icon
30
Immatics
IMTX
$662M
$59.5M 0.29%
4,423,731
– –
CCXI
31
DELISTED
ChemoCentryx, Inc.
CCXI
$59.4M 0.29%
1,631,266
+1,330,071
+442% +$48.4M
INSM icon
32
Insmed
INSM
$30.3B
$58.7M 0.29%
2,156,001
– –
NBIX icon
33
Neurocrine Biosciences
NBIX
$13.5B
$57.7M 0.28%
676,975
– –
KRYS icon
34
Krystal Biotech
KRYS
$4.35B
$56.5M 0.27%
807,735
+200,000
+33% +$14M
VERV
35
DELISTED
Verve Therapeutics
VERV
$52.2M 0.25%
1,416,530
– –
VSTM icon
36
Verastem
VSTM
$585M
$44.1M 0.21%
1,790,969
– –
RYTM icon
37
Rhythm Pharmaceuticals
RYTM
$6.75B
$38.6M 0.19%
3,863,239
– –
KDNY
38
DELISTED
Chinook Therapeutics, Inc. Common Stock
KDNY
$38.1M 0.19%
2,334,102
+431,033
+23% +$7.03M
RARE icon
39
Ultragenyx Pharmaceutical
RARE
$3.04B
$37.4M 0.18%
444,444
– –
ADAP
40
Adaptimmune Therapeutics
ADAP
$13.9M
$36.9M 0.18%
9,830,877
– –
ALKS icon
41
Alkermes
ALKS
$4.95B
$34.9M 0.17%
1,500,000
+271,830
+22% +$6.32M
KNSA icon
42
Kiniksa Pharmaceuticals
KNSA
$2.63B
$33M 0.16%
2,799,577
– –
DSGN icon
43
Design Therapeutics
DSGN
$339M
$30.8M 0.15%
1,436,636
– –
TLIS
44
DELISTED
Talis Biomedical Corporation Common Stock
TLIS
$30.6M 0.15%
508,322
+3,333
+0.7% +$200K
FMTX
45
DELISTED
Forma Therapeutics Holdings, Inc. Common Stock
FMTX
$28.8M 0.14%
2,024,876
– –
ZYME icon
46
Zymeworks
ZYME
$1.07B
$28M 0.14%
1,708,472
– –
BLUE
47
DELISTED
bluebird bio
BLUE
$25M 0.12%
124,986
-67,992
-35% -$13.6M
ALGS icon
48
Aligos Therapeutics
ALGS
$75.1M
$24.6M 0.12%
83,056
– –
OPT
49
DELISTED
Opthea Limited American Depositary Shares
OPT
$24.1M 0.12%
3,196,191
-186,606
-6% -$1.41M
CRNX icon
50
Crinetics Pharmaceuticals
CRNX
$3.26B
$23.5M 0.11%
827,480
-93,176
-10% -$2.65M
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