UPB

Upstream Bio, Inc. Common Stock
UPB

Overview Fund Activity

70 hedge funds and large institutions have $690M invested in Upstream Bio, Inc. Common Stock in 2024 Q4 according to their latest regulatory filings, with 70 funds opening new positions, increasing their positions, reducing their positions, and closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
70
Holders Change
+70
Holders Change %
–
% of All Funds
0.93%
Holding in Top 10
6
Holding in Top 10 Change
+6
Holding in Top 10 Change %
%
% of All Funds
0.08%
New
70
Increased
–
Reduced
–
Closed
–
Calls
–
Puts
–
Net Calls
–
Net Calls Change
–

Top Buyers

1
Fidelity Investments
1
Fidelity Investments
Massachusetts
$118M
2
O
2
OrbiMed
New York
$93.6M
3
DC
3
Decheng Capital
California
$54M
4
TCM
4
TCG Crossover Management
California
$44.9M
5
BCLSI
5
Bain Capital Life Sciences Investors
Massachusetts
$37.7M

Top Sellers

No sellers this quarter
Name Holding Trade Value Shares
Change 		Shares
Change %
UBS Group
26
UBS Group
Switzerland
$2.66M +$2.66M +161,512 New
Northern Trust
27
Northern Trust
Illinois
$2.36M +$2.36M +143,721 New
Charles Schwab
28
Charles Schwab
California
$2.22M +$2.22M +135,323 New
Alyeska Investment Group
29
Alyeska Investment Group
Illinois
$1.4M +$1.4M +85,000 New
MAP
30
Moody Aldrich Partners
Massachusetts
$1.23M +$1.23M +74,773 New
EC
31
EcoR1 Capital
California
$986K +$986K +60,000 New
JPMorgan Chase & Co
32
JPMorgan Chase & Co
New York
$786K +$786K +47,792 New
SFM
33
Soros Fund Management
New York
$762K +$762K +46,350 New
Jane Street
34
Jane Street
New York
$749K +$749K +45,549 New
Goldman Sachs
35
Goldman Sachs
New York
$731K +$731K +44,490 New
AA
36
ALPS Advisors
Colorado
$713K +$713K +43,340 New
Morgan Stanley
37
Morgan Stanley
New York
$710K +$710K +43,163 New
Verition Fund Management
38
Verition Fund Management
Connecticut
$615K +$615K +37,379 New
Bank of New York Mellon
39
Bank of New York Mellon
New York
$607K +$607K +36,913 New
Barclays
40
Barclays
United Kingdom
$445K +$445K +27,017 New
Citigroup
41
Citigroup
New York
$436K +$436K +26,504 New
Nuveen Asset Management
42
Nuveen Asset Management
Illinois
$371K +$371K +22,586 New
RhumbLine Advisers
43
RhumbLine Advisers
Massachusetts
$275K +$275K +16,721 New
Invesco
44
Invesco
Georgia
$256K +$256K +15,602 New
Deutsche Bank
45
Deutsche Bank
Germany
$244K +$244K +14,851 New
Bank of America
46
Bank of America
North Carolina
$230K +$230K +13,963 New
DKCM
47
Davidson Kempner Capital Management
New York
$205K +$205K +12,500 New
MIM
48
MetLife Investment Management
New Jersey
$181K +$181K +11,034 New
Walleye Capital
49
Walleye Capital
New York
$164K +$164K +10,000 New
SIM
50
Sandia Investment Management
Massachusetts
$164K +$164K +10,000 New
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2
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