MetLife Investment Management
UPB icon

MetLife Investment Management’s Upstream Bio Inc UPB Stock Holding History

MetLife Investment Management’s Portfolio UPB Stock Details UPB Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q2 		$144K Buy
20,852
+1,472
+8% +$12.3K ﹤0.01% 2594
2026
Q1 		$174K Sell
19,380
-298
-2% -$5.36K ﹤0.01% 2298
2025
Q4 		$534K Sell
19,678
-2,013
-9% -$50.1K ﹤0.01% 1764
2025
Q3 		$408K Hold
21,691
– – ﹤0.01% 1904
2025
Q2 		$238K Buy
21,691
+10,657
+97% +$98.4K ﹤0.01% 2098
2025
Q1 		$67.5K Hold
11,034
– – ﹤0.01% 2657
2024
Q4 		$181K Buy
+11,034
New +$246K ﹤0.01% 2349

Other funds holding UPB

Fidelity Investments
Fidelity Investments Boston, Massachusetts $2.3T AUM 54.33% 1-Year Est. Return
OrbiMed
OrbiMed New York $5.4B AUM 163.13% 1-Year Est. Return
Norges Bank
Norges Bank Oslo, Norway $1T AUM
BlackRock
BlackRock New York $6.73T AUM 46.02% 1-Year Est. Return
DC
Decheng Capital Menlo Park, California $732M AUM 275.56% 1-Year Est. Return
ES
Enavate Sciences Menlo Park, California $345M AUM 134.64% 1-Year Est. Return
Vanguard Capital Management
Vanguard Capital Management Malvern, Pennsylvania $4.68T AUM
Millennium Management
Millennium Management New York $276B AUM 44.8% 1-Year Est. Return
D.E. Shaw & Co
D.E. Shaw & Co New York $210B AUM 57.28% 1-Year Est. Return
JP Morgan Chase
JP Morgan Chase New York $1.81T AUM 41.13% 1-Year Est. Return

MetLife Investment Management's UPB Position: Q2 2026 in Review

MetLife Investment Management increased its Upstream Bio Inc (UPB) stake by 7.6% in Q2 2026, buying an estimated $12.3K and bringing the position to 20,852 shares worth $144K. The position accounts for ﹤0.01% of the portfolio, ranked #2594.

MetLife Investment Management first reported a position in UPB in Q4 2024 and has held it in 7 quarters since. The position peaked at $534K in Q4 2025. 148 funds tracked by Wall St. Rank hold UPB as of Q2 2026.

  • MetLife Investment Management held 20,852 shares of Upstream Bio Inc worth $144K as of Q2 2026.
  • MetLife Investment Management bought 1,472 Upstream Bio Inc shares in Q2 2026, an estimated $12.3K.
  • Upstream Bio Inc made up ﹤0.01% of MetLife Investment Management's portfolio in Q2 2026, its #2594 holding.
  • MetLife Investment Management first reported a position in Upstream Bio Inc in Q4 2024 and has held it in 7 quarters since.
  • MetLife Investment Management's Upstream Bio Inc position peaked at $534K in Q4 2025.
  • 148 funds tracked by Wall St. Rank held Upstream Bio Inc as of Q2 2026.

Based on MetLife Investment Management's 13F filing for Q2 2026, filed 14 Aug 2026.