|
1
|
Fidelity Investments
Boston,
Massachusetts
|
$443M
|
+$69.5M
|
+1,639,283
|
+16%
|
|
|
2
|
RA Capital Management
Boston,
Massachusetts
|
$273M
|
+$60.8M
|
+1,433,795
|
+24%
|
|
|
3
|
Janus Henderson Group
London,
|
$267M
|
+$48.9M
|
+1,153,472
|
+19%
|
|
|
4
|
Vanguard Group
Malvern,
Pennsylvania
|
$245M
|
-$3.45M
|
-81,350
|
-1%
|
|
|
5
|
|
$190M
|
-$997K
|
-23,505
|
-0.5%
|
|
|
6
|
Wellington Management Group
Boston,
Massachusetts
|
$121M
|
-$12.3M
|
-288,840
|
-8%
|
|
|
7
|
State Street
Boston,
Massachusetts
|
$115M
|
-$3.9M
|
-91,965
|
-3%
|
|
|
8
|
Capital Research Global Investors
Los Angeles,
California
|
$107M
|
+$1.99M
|
+47,004
|
+2%
|
|
|
9
|
Carlyle Group
Washington,
District of Columbia
|
$72.1M
|
+$81.6M
|
+1,923,158
|
New
|
|
|
10
|
Medicxi Ventures Management
St. Helier,
Jersey
|
$54.6M
|
–
|
–
|
–
|
|
|
11
|
Jennison Associates
New York
|
$53.6M
|
+$341K
|
+8,032
|
+0.6%
|
|
|
12
|
Frazier Life Sciences Management
Palo Alto,
California
|
$52.4M
|
–
|
–
|
–
|
|
|
13
|
Geode Capital Management
Boston,
Massachusetts
|
$49.8M
|
+$3.3M
|
+77,906
|
+6%
|
|
|
14
|
Braidwell
Stamford,
Connecticut
|
$49.5M
|
-$1.79M
|
-42,300
|
-3%
|
|
|
15
|
Millennium Management
New York
|
$49.2M
|
+$3.99M
|
+94,151
|
+8%
|
|
|
16
|
Kynam Capital Management
Princeton,
New Jersey
|
$45.6M
|
+$21.8M
|
+513,343
|
+73%
|
|
|
17
|
TPG GP A
Fort Worth,
Texas
|
$44.6M
|
–
|
–
|
–
|
|
|
18
|
Perceptive Advisors
New York
|
$43.9M
|
–
|
–
|
–
|
|
|
19
|
Citadel Advisors
Miami,
Florida
|
$32M
|
+$95.5K
|
+2,252
|
+0.3%
|
|
|
20
|
Fred Alger Management
New York
|
$31.7M
|
-$1.38M
|
-32,515
|
-4%
|
|
|
21
|
|
$29.8M
|
-$7.53M
|
-177,414
|
-18%
|
|
|
22
|
Novo Holdings A/S
Hellerup,
Denmark
|
$27.9M
|
+$848K
|
+20,000
|
+3%
|
|
|
23
|
T. Rowe Price Investment Management
Baltimore,
Maryland
|
$27.5M
|
+$9.44M
|
+222,471
|
+43%
|
|
|
24
|
|
$27.3M
|
-$23.5M
|
-553,687
|
-43%
|
|
|
25
|
Franklin Resources
San Mateo,
California
|
$26.8M
|
+$30.2M
|
+711,039
|
+13,674%
|
|
