|
1
|
Fidelity Investments
Boston,
Massachusetts
|
$199M
|
+$2.95M
|
+121,576
|
+2%
|
|
|
2
|
TPG Group Holdings (SBS) Advisors
Fort Worth,
Texas
|
$108M
|
-$7.37M
|
-304,085
|
-7%
|
|
|
3
|
Abingworth
London,
United Kingdom
|
$106M
|
–
|
–
|
–
|
|
|
4
|
Janus Henderson Group
London,
|
$104M
|
-$569K
|
-23,493
|
-0.6%
|
|
|
5
|
RA Capital Management
Boston,
Massachusetts
|
$98.9M
|
+$753K
|
+31,057
|
+0.8%
|
|
|
6
|
Vanguard Group
Malvern,
Pennsylvania
|
$77.2M
|
+$4.73M
|
+195,238
|
+7%
|
|
|
7
|
|
$64.1M
|
+$4.32M
|
+178,028
|
+8%
|
|
|
8
|
Frazier Management
Seattle,
Washington
|
$58.6M
|
–
|
–
|
–
|
|
|
9
|
Medicxi Ventures Management
St. Helier,
Jersey
|
$47.9M
|
–
|
–
|
–
|
|
|
10
|
Pivotal bioVenture Partners Investment Advisor
San Francisco,
California
|
$35.7M
|
–
|
–
|
–
|
|
|
11
|
State Street
Boston,
Massachusetts
|
$28.8M
|
-$8.9M
|
-367,009
|
-24%
|
|
|
12
|
Wellington Management Group
Boston,
Massachusetts
|
$26.3M
|
+$3.88M
|
+160,096
|
+18%
|
|
|
13
|
|
$26.2M
|
+$2.16M
|
+89,265
|
+9%
|
|
|
14
|
Geode Capital Management
Boston,
Massachusetts
|
$16M
|
+$2.7M
|
+111,593
|
+22%
|
|
|
15
|
Northern Trust
Chicago,
Illinois
|
$9.52M
|
+$229K
|
+9,455
|
+3%
|
|
|
16
|
Soleus Capital Management
Greenwich,
Connecticut
|
$9.02M
|
-$485K
|
-20,000
|
-5%
|
|
|
17
|
Opaleye Management
Boston,
Massachusetts
|
$8.97M
|
-$107K
|
-4,400
|
-1%
|
|
|
18
|
Ikarian Capital
Dallas,
Texas
|
$7.49M
|
-$3.71M
|
-152,999
|
-34%
|
|
|
19
|
Millennium Management
New York
|
$7.14M
|
-$832K
|
-34,329
|
-11%
|
|
|
20
|
|
$6.25M
|
+$1.47M
|
+60,709
|
+33%
|
|
|
21
|
Charles Schwab
San Francisco,
California
|
$6.03M
|
+$1.58M
|
+65,145
|
+38%
|
|
|
22
|
State of Wisconsin Investment Board
Madison,
Wisconsin
|
$4.27M
|
+$960K
|
+39,605
|
+31%
|
|
|
23
|
Ghost Tree Capital
New York
|
$4.06M
|
+$364K
|
+15,000
|
+10%
|
|
|
24
|
Nuveen
Charlotte,
North Carolina
|
$3.88M
|
-$190K
|
-7,855
|
-5%
|
|
|
25
|
Bank of New York Mellon
New York
|
$3.49M
|
+$463K
|
+19,092
|
+16%
|
|
