|
1
|
Fidelity Investments
Boston,
Massachusetts
|
$315M
|
+$66.5M
|
+1,669,004
|
+35%
|
|
|
2
|
RA Capital Management
Boston,
Massachusetts
|
$261M
|
-$8.18M
|
-205,363
|
-4%
|
|
|
3
|
TPG Group Holdings (SBS) Advisors
Fort Worth,
Texas
|
$255M
|
–
|
–
|
–
|
|
|
4
|
Abingworth
London,
United Kingdom
|
$206M
|
–
|
–
|
–
|
|
|
5
|
Janus Henderson Group
London,
|
$200M
|
-$21.1M
|
-529,363
|
-11%
|
|
|
6
|
Frazier Management
Seattle,
Washington
|
$114M
|
–
|
–
|
–
|
|
|
7
|
Medicxi Ventures Management
St. Helier,
Jersey
|
$93.2M
|
–
|
–
|
–
|
|
|
8
|
Vanguard Group
Malvern,
Pennsylvania
|
$66.8M
|
+$52.7M
|
+1,322,820
|
+4,409%
|
|
|
9
|
Wellington Management Group
Boston,
Massachusetts
|
$54.2M
|
-$4.07M
|
-102,144
|
-9%
|
|
|
10
|
|
$49.6M
|
+$36.8M
|
+924,716
|
+1,159%
|
|
|
11
|
Perceptive Advisors
New York
|
$42M
|
–
|
–
|
–
|
|
|
12
|
Novo Holdings A/S
Hellerup,
Denmark
|
$32.2M
|
-$9.18M
|
-230,643
|
-26%
|
|
|
13
|
|
$31.6M
|
-$8.33M
|
-209,240
|
-25%
|
|
|
14
|
Foresite Capital Management IV
Larkspur,
California
|
$23M
|
-$6.17M
|
-155,000
|
-25%
|
|
|
15
|
Franklin Resources
San Mateo,
California
|
$19.8M
|
–
|
–
|
–
|
|
|
16
|
Opaleye Management
Boston,
Massachusetts
|
$15.5M
|
+$12.5M
|
+313,000
|
New
|
|
|
17
|
Geode Capital Management
Boston,
Massachusetts
|
$14.4M
|
+$10.6M
|
+266,887
|
+1,046%
|
|
|
18
|
State Street
Boston,
Massachusetts
|
$13.5M
|
+$10.9M
|
+274,041
|
New
|
|
|
19
|
Northern Trust
Chicago,
Illinois
|
$10.6M
|
+$8.54M
|
+214,527
|
New
|
|
|
20
|
Charles Schwab
San Francisco,
California
|
$5.73M
|
+$4.62M
|
+116,065
|
New
|
|
|
21
|
Nuveen
Charlotte,
North Carolina
|
$3.83M
|
+$3.09M
|
+77,659
|
New
|
|
|
22
|
Bank of New York Mellon
New York
|
$2.62M
|
+$2.11M
|
+53,015
|
New
|
|
|
23
|
Citadel Advisors
Miami,
Florida
|
$2.6M
|
-$19.8M
|
-497,192
|
-90%
|
|
|
24
|
California Public Employees Retirement System
Sacramento,
California
|
$2.03M
|
+$1.64M
|
+41,086
|
New
|
|
|
25
|
ETF Managers Group
Summit,
New Jersey
|
$1.48M
|
+$1.15M
|
+28,778
|
New
|
|
