|
1
|
Fidelity Investments
Boston,
Massachusetts
|
$187M
|
+$1.07M
|
+45,965
|
+0.6%
|
|
|
2
|
Janus Henderson Group
London,
|
$101M
|
+$3.56M
|
+153,198
|
+4%
|
|
|
3
|
RA Capital Management
Boston,
Massachusetts
|
$101M
|
+$7.99M
|
+343,599
|
+9%
|
|
|
4
|
TPG GP A
Fort Worth,
Texas
|
$100M
|
+$97.9M
|
+4,207,575
|
New
|
|
|
5
|
Abingworth
London,
United Kingdom
|
$99.2M
|
–
|
–
|
–
|
|
|
6
|
Vanguard Group
Malvern,
Pennsylvania
|
$74.6M
|
+$2.1M
|
+90,404
|
+3%
|
|
|
7
|
|
$66.1M
|
+$5.87M
|
+252,402
|
+10%
|
|
|
8
|
Frazier Management
Seattle,
Washington
|
$54.9M
|
–
|
–
|
–
|
|
|
9
|
Medicxi Ventures Management
St. Helier,
Jersey
|
$44.9M
|
–
|
–
|
–
|
|
|
10
|
State Street
Boston,
Massachusetts
|
$28M
|
+$900K
|
+38,677
|
+3%
|
|
|
11
|
Wellington Management Group
Boston,
Massachusetts
|
$27.4M
|
+$2.67M
|
+114,804
|
+11%
|
|
|
12
|
Pivotal bioVenture Partners Investment Advisor
San Francisco,
California
|
$26.4M
|
-$6.84M
|
-293,936
|
-21%
|
|
|
13
|
|
$26.1M
|
+$1.44M
|
+62,035
|
+6%
|
|
|
14
|
Geode Capital Management
Boston,
Massachusetts
|
$15.6M
|
+$585K
|
+25,150
|
+4%
|
|
|
15
|
Great Point Partners
Greenwich,
Connecticut
|
$11.9M
|
+$9.35M
|
+401,939
|
+410%
|
|
|
16
|
Northern Trust
Chicago,
Illinois
|
$8.84M
|
-$84.8K
|
-3,645
|
-1%
|
|
|
17
|
Opaleye Management
Boston,
Massachusetts
|
$7.51M
|
-$874K
|
-37,600
|
-11%
|
|
|
18
|
Ikarian Capital
Dallas,
Texas
|
$7.02M
|
–
|
–
|
–
|
|
|
19
|
Soleus Capital Management
Greenwich,
Connecticut
|
$7.01M
|
-$1.42M
|
-60,900
|
-17%
|
|
|
20
|
Millennium Management
New York
|
$6.81M
|
+$117K
|
+5,039
|
+2%
|
|
|
21
|
Ghost Tree Capital
New York
|
$5.95M
|
+$2.09M
|
+90,000
|
+56%
|
|
|
22
|
Charles Schwab
San Francisco,
California
|
$5.76M
|
+$106K
|
+4,571
|
+2%
|
|
|
23
|
Kynam Capital Management
Princeton,
New Jersey
|
$5.03M
|
+$4.92M
|
+211,483
|
New
|
|
|
24
|
State of Wisconsin Investment Board
Madison,
Wisconsin
|
$4.93M
|
+$906K
|
+38,960
|
+23%
|
|
|
25
|
|
$4.72M
|
-$1.11M
|
-47,817
|
-19%
|
|
