|
1
|
Fidelity Investments
Boston,
Massachusetts
|
$173M
|
+$157K
|
+7,666
|
+0.1%
|
|
|
2
|
TPG Group Holdings (SBS) Advisors
Fort Worth,
Texas
|
$103M
|
–
|
–
|
–
|
|
|
3
|
Abingworth
London,
United Kingdom
|
$93.6M
|
–
|
–
|
–
|
|
|
4
|
Janus Henderson Group
London,
|
$92.7M
|
-$2.32M
|
-113,348
|
-3%
|
|
|
5
|
RA Capital Management
Boston,
Massachusetts
|
$87M
|
–
|
–
|
–
|
|
|
6
|
Vanguard Group
Malvern,
Pennsylvania
|
$64.1M
|
+$1.58M
|
+77,330
|
+3%
|
|
|
7
|
|
$52.8M
|
+$3.23M
|
+157,889
|
+7%
|
|
|
8
|
Frazier Management
Seattle,
Washington
|
$52M
|
–
|
–
|
–
|
|
|
9
|
Medicxi Ventures Management
St. Helier,
Jersey
|
$42.5M
|
–
|
–
|
–
|
|
|
10
|
State Street
Boston,
Massachusetts
|
$33.8M
|
-$5.5M
|
-268,813
|
-15%
|
|
|
11
|
Pivotal bioVenture Partners Investment Advisor
San Francisco,
California
|
$31.6M
|
–
|
–
|
–
|
|
|
12
|
|
$21.3M
|
+$6.07M
|
+296,626
|
+46%
|
|
|
13
|
Wellington Management Group
Boston,
Massachusetts
|
$19.8M
|
-$2.46M
|
-120,285
|
-12%
|
|
|
14
|
Geode Capital Management
Boston,
Massachusetts
|
$11.7M
|
+$2.01M
|
+98,086
|
+23%
|
|
|
15
|
Ikarian Capital
Dallas,
Texas
|
$10.1M
|
-$1.09M
|
-53,000
|
-11%
|
|
|
16
|
Soleus Capital Management
Greenwich,
Connecticut
|
$8.46M
|
+$1.68M
|
+82,000
|
+28%
|
|
|
17
|
Northern Trust
Chicago,
Illinois
|
$8.23M
|
+$1.53M
|
+74,694
|
+26%
|
|
|
18
|
Opaleye Management
Boston,
Massachusetts
|
$8.05M
|
–
|
–
|
–
|
|
|
19
|
Millennium Management
New York
|
$7.1M
|
-$775K
|
-37,841
|
-11%
|
|
|
20
|
|
$4.18M
|
+$91.8K
|
+4,485
|
+2%
|
|
|
21
|
Charles Schwab
San Francisco,
California
|
$3.89M
|
+$746K
|
+36,425
|
+27%
|
|
|
22
|
Nuveen
Charlotte,
North Carolina
|
$3.62M
|
+$1.33M
|
+65,143
|
+68%
|
|
|
23
|
Ghost Tree Capital
New York
|
$3.26M
|
+$2.97M
|
+145,000
|
New
|
|
|
24
|
State of Wisconsin Investment Board
Madison,
Wisconsin
|
$2.9M
|
+$515K
|
+25,155
|
+24%
|
|
|
25
|
Bank of New York Mellon
New York
|
$2.67M
|
+$689K
|
+33,669
|
+40%
|
|
