|
1
|
Fidelity Investments
Boston,
Massachusetts
|
$203M
|
+$47.1M
|
+1,266,642
|
+20%
|
|
|
2
|
TPG Group Holdings (SBS) Advisors
Fort Worth,
Texas
|
$131M
|
-$8.01M
|
-215,340
|
-4%
|
|
|
3
|
Abingworth
London,
United Kingdom
|
$111M
|
–
|
–
|
–
|
|
|
4
|
Janus Henderson Group
London,
|
$108M
|
+$13K
|
+349
|
+0%
|
|
|
5
|
RA Capital Management
Boston,
Massachusetts
|
$98.6M
|
-$58.5M
|
-1,573,119
|
-30%
|
|
|
6
|
Frazier Management
Seattle,
Washington
|
$61.4M
|
–
|
–
|
–
|
|
|
7
|
Pivotal bioVenture Partners Investment Advisor
San Francisco,
California
|
$59.1M
|
+$82.6M
|
+2,222,970
|
New
|
|
|
8
|
Medicxi Ventures Management
St. Helier,
Jersey
|
$50.1M
|
–
|
–
|
–
|
|
|
9
|
|
$45M
|
+$25.6M
|
+688,500
|
+69%
|
|
|
10
|
Vanguard Group
Malvern,
Pennsylvania
|
$38.5M
|
+$3.59M
|
+96,557
|
+7%
|
|
|
11
|
Wellington Management Group
Boston,
Massachusetts
|
$26.9M
|
-$3.23M
|
-87,006
|
-8%
|
|
|
12
|
State Street
Boston,
Massachusetts
|
$24.5M
|
+$24.1M
|
+647,789
|
+236%
|
|
|
13
|
Perceptive Advisors
New York
|
$22.6M
|
–
|
–
|
–
|
|
|
14
|
|
$16.7M
|
-$390K
|
-10,500
|
-2%
|
|
|
15
|
Foresite Capital Management IV
Larkspur,
California
|
$12.4M
|
–
|
–
|
–
|
|
|
16
|
Millennium Management
New York
|
$11.3M
|
+$12.3M
|
+330,164
|
+345%
|
|
|
17
|
Novo Holdings A/S
Hellerup,
Denmark
|
$11.1M
|
-$8.71M
|
-234,318
|
-36%
|
|
|
18
|
Franklin Resources
San Mateo,
California
|
$10.6M
|
+$223
|
+6
|
+0%
|
|
|
19
|
Opaleye Management
Boston,
Massachusetts
|
$8.91M
|
+$825K
|
+22,200
|
+7%
|
|
|
20
|
Geode Capital Management
Boston,
Massachusetts
|
$7.99M
|
+$304K
|
+8,164
|
+3%
|
|
|
21
|
|
$7.86M
|
+$11M
|
+295,908
|
New
|
|
|
22
|
Ikarian Capital
Dallas,
Texas
|
$7.34M
|
+$9.67M
|
+260,000
|
+1,614%
|
|
|
23
|
Northern Trust
Chicago,
Illinois
|
$5.93M
|
+$319K
|
+8,593
|
+4%
|
|
|
24
|
Citadel Advisors
Miami,
Florida
|
$5.18M
|
+$5.29M
|
+142,252
|
+271%
|
|
|
25
|
Logos Global Management
San Francisco,
California
|
$3.72M
|
+$5.2M
|
+140,000
|
New
|
|
