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Name Holding Trade Value Shares
Change 		Change in
Stake
RCM
1
RA Capital Management
Massachusetts
$174M +$177M +5,489,181 New
TGHSA
2
TPG Group Holdings (SBS) Advisors
Texas
$163M +$166M +5,156,553 New
Fidelity Investments
3
Fidelity Investments
Massachusetts
$149M +$151M +4,706,759 New
Janus Henderson Group
4
Janus Henderson Group
$140M +$152M +4,725,792 New
A
5
Abingworth
United Kingdom
$132M +$134M +4,168,718 New
FM
6
Frazier Management
Washington
$73M +$74.3M +2,309,554 New
MVM
7
Medicxi Ventures Management
Jersey
$59.7M +$60.7M +1,887,478 New
Wellington Management Group
8
Wellington Management Group
Massachusetts
$37.9M +$38.6M +1,200,000 New
NHAS
9
Novo Holdings A/S
Denmark
$27.9M +$28.4M +881,898 New
Millennium Management
10
Millennium Management
New York
$27.4M +$27.9M +868,318 New
O
11
OrbiMed
New York
$26.9M +$27.3M +850,000 New
PA
12
Perceptive Advisors
New York
$26.9M +$27.3M +850,000 New
FCMI
13
Foresite Capital Management IV
California
$19.6M +$20M +620,821 New
Citadel Advisors
14
Citadel Advisors
Florida
$17.4M +$17.7M +549,751 New
LGM
15
Logos Global Management
California
$14.4M +$14.6M +455,000 New
Franklin Resources
16
Franklin Resources
California
$12.7M +$12.9M +400,070 New
VOYA Investment Management
17
VOYA Investment Management
Georgia
$6.52M +$6.64M +206,322 New
IC
18
Ikarian Capital
Texas
$4.42M +$4.5M +139,813 New
Goldman Sachs
19
Goldman Sachs
New York
$2.76M +$2.81M +87,424 New
MIM
20
Monashee Investment Management
Massachusetts
$2.53M +$2.57M +80,000 New
BlackRock
21
BlackRock
New York
$2.52M +$2.57M +79,812 New
MWNA
22
Marshall Wace North America
New York
$1.23M +$1.25M +38,856 New
Vanguard Group
23
Vanguard Group
Pennsylvania
$948K +$965K +30,000 New
Geode Capital Management
24
Geode Capital Management
Massachusetts
$806K +$821K +25,526 New
WP
25
Woodline Partners
California
$728K +$740K +23,026 New
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