|
1
|
Fidelity Investments
Boston,
Massachusetts
|
$488M
|
+$49.9M
|
+1,272,085
|
+14%
|
|
|
2
|
Vanguard Group
Malvern,
Pennsylvania
|
$317M
|
+$84.8M
|
+2,161,521
|
+49%
|
|
|
3
|
Janus Henderson Group
London,
|
$286M
|
-$122M
|
-3,101,363
|
-34%
|
|
|
4
|
RA Capital Management
Boston,
Massachusetts
|
$281M
|
+$50.1M
|
+1,276,256
|
+28%
|
|
|
5
|
|
$245M
|
+$63.3M
|
+1,613,049
|
+46%
|
|
|
6
|
Wellington Management Group
Boston,
Massachusetts
|
$169M
|
+$69.8M
|
+1,779,193
|
+102%
|
|
|
7
|
State Street
Boston,
Massachusetts
|
$152M
|
+$46.1M
|
+1,174,945
|
+59%
|
|
|
8
|
Capital Research Global Investors
Los Angeles,
California
|
$135M
|
+$89.9M
|
+2,291,146
|
+445%
|
|
|
9
|
Abingworth
London,
United Kingdom
|
$96.8M
|
-$84.4M
|
-2,149,661
|
-52%
|
|
|
10
|
Avidity Partners Management
Dallas,
Texas
|
$77.5M
|
+$38.7M
|
+986,700
|
+157%
|
|
|
11
|
Medicxi Ventures Management
St. Helier,
Jersey
|
$69.9M
|
-$16.9M
|
-430,178
|
-23%
|
|
|
12
|
Jennison Associates
New York
|
$68.2M
|
+$55.8M
|
+1,422,007
|
New
|
|
|
13
|
Frazier Life Sciences Management
Palo Alto,
California
|
$67M
|
-$5.89M
|
-150,000
|
-10%
|
|
|
14
|
Braidwell
Stamford,
Connecticut
|
$65.3M
|
+$53.5M
|
+1,362,278
|
New
|
|
|
15
|
|
$61.5M
|
+$22.2M
|
+565,226
|
+79%
|
|
|
16
|
Geode Capital Management
Boston,
Massachusetts
|
$60M
|
+$14M
|
+356,647
|
+40%
|
|
|
17
|
Millennium Management
New York
|
$58.5M
|
+$17M
|
+433,169
|
+55%
|
|
|
18
|
TPG GP A
Fort Worth,
Texas
|
$57.1M
|
-$82.2M
|
-2,095,168
|
-64%
|
|
|
19
|
Perceptive Advisors
New York
|
$56.1M
|
+$45.9M
|
+1,170,000
|
New
|
|
|
20
|
|
$46.6M
|
+$38.2M
|
+972,321
|
New
|
|
|
21
|
Fred Alger Management
New York
|
$42.1M
|
+$34.4M
|
+877,293
|
New
|
|
|
22
|
Citadel Advisors
Miami,
Florida
|
$40.8M
|
+$745K
|
+18,991
|
+2%
|
|
|
23
|
Driehaus Capital Management
Chicago,
Illinois
|
$39.8M
|
+$9.7M
|
+247,189
|
+42%
|
|
|
24
|
Great Point Partners
Greenwich,
Connecticut
|
$38.4M
|
+$7.85M
|
+200,000
|
+33%
|
|
|
25
|
Adage Capital Partners
Boston,
Massachusetts
|
$38.1M
|
+$27.3M
|
+695,000
|
+695%
|
|
