|
1
|
Janus Henderson Group
London,
|
$218M
|
+$123M
|
+4,851,015
|
+115%
|
|
|
2
|
Fidelity Investments
Boston,
Massachusetts
|
$214M
|
+$9.73M
|
+383,791
|
+5%
|
|
|
3
|
RA Capital Management
Boston,
Massachusetts
|
$110M
|
–
|
–
|
–
|
|
|
4
|
Vanguard Group
Malvern,
Pennsylvania
|
$107M
|
+$12.6M
|
+496,227
|
+13%
|
|
|
5
|
Abingworth
London,
United Kingdom
|
$100M
|
–
|
–
|
–
|
|
|
6
|
|
$83.8M
|
+$5.59M
|
+220,691
|
+7%
|
|
|
7
|
TPG GP A
Fort Worth,
Texas
|
$78.9M
|
-$9.68M
|
-381,921
|
-10%
|
|
|
8
|
State Street
Boston,
Massachusetts
|
$47.8M
|
+$3.48M
|
+137,392
|
+7%
|
|
|
9
|
Medicxi Ventures Management
St. Helier,
Jersey
|
$45.3M
|
–
|
–
|
–
|
|
|
10
|
Wellington Management Group
Boston,
Massachusetts
|
$42M
|
+$41.1M
|
+1,619,700
|
+1,253%
|
|
|
11
|
Frazier Life Sciences Management
Palo Alto,
California
|
$37.1M
|
-$6.08M
|
-240,000
|
-13%
|
|
|
12
|
Geode Capital Management
Boston,
Massachusetts
|
$21.5M
|
+$2.92M
|
+115,091
|
+15%
|
|
|
13
|
National Bank of Canada
Montreal,
Quebec, Canada
|
$21.3M
|
+$22.4M
|
+885,538
|
New
|
|
|
14
|
Citadel Advisors
Miami,
Florida
|
$20M
|
-$4.31M
|
-170,119
|
-17%
|
|
|
15
|
Novo Holdings A/S
Hellerup,
Denmark
|
$19.8M
|
–
|
–
|
–
|
|
|
16
|
Millennium Management
New York
|
$18.9M
|
+$5.58M
|
+220,206
|
+39%
|
|
|
17
|
Pivotal bioVenture Partners Investment Advisor
San Francisco,
California
|
$18.6M
|
-$1.42M
|
-56,127
|
-7%
|
|
|
18
|
Kynam Capital Management
Princeton,
New Jersey
|
$16.8M
|
-$637K
|
-25,143
|
-3%
|
|
|
19
|
Avidity Partners Management
Dallas,
Texas
|
$15.1M
|
+$15.9M
|
+628,700
|
New
|
|
|
20
|
Great Point Partners
Greenwich,
Connecticut
|
$14.4M
|
-$9.76M
|
-385,153
|
-39%
|
|
|
21
|
Driehaus Capital Management
Chicago,
Illinois
|
$14M
|
+$898K
|
+35,416
|
+6%
|
|
|
22
|
Capital Research Global Investors
Los Angeles,
California
|
$12.7M
|
+$13.1M
|
+514,856
|
New
|
|
|
23
|
|
$11.7M
|
+$3.41M
|
+134,502
|
+38%
|
|
|
24
|
Northern Trust
Chicago,
Illinois
|
$11.6M
|
+$496K
|
+19,555
|
+4%
|
|
|
25
|
Point72 Asset Management
Stamford,
Connecticut
|
$10.1M
|
+$10.7M
|
+422,800
|
New
|
|
