|
1
|
RA Capital Management
Boston,
Massachusetts
|
$105M
|
–
|
–
|
–
|
|
|
2
|
Fidelity Investments
Boston,
Massachusetts
|
$62.2M
|
-$7.74M
|
-465,216
|
-8%
|
|
|
3
|
EcoR1 Capital
San Francisco,
California
|
$46.4M
|
+$40.2M
|
+2,417,167
|
+170%
|
|
|
4
|
|
$34.3M
|
–
|
–
|
–
|
|
|
5
|
Janus Henderson Group
London,
|
$22.6M
|
+$521K
|
+31,285
|
+2%
|
|
|
6
|
Citadel Advisors
Miami,
Florida
|
$22.4M
|
-$29.7K
|
-1,785
|
-0.1%
|
|
|
7
|
BVF Inc
San Francisco,
California
|
$19.2M
|
+$1.92M
|
+115,343
|
+8%
|
|
|
8
|
|
$13.7M
|
+$526K
|
+31,590
|
+3%
|
|
|
9
|
Adage Capital Partners
Boston,
Massachusetts
|
$10.9M
|
+$3.31M
|
+198,934
|
+28%
|
|
|
10
|
Vanguard Group
Malvern,
Pennsylvania
|
$9.35M
|
+$300K
|
+18,035
|
+2%
|
|
|
11
|
Samsara BioCapital
Palo Alto,
California
|
$4.36M
|
–
|
–
|
–
|
|
|
12
|
Geode Capital Management
Boston,
Massachusetts
|
$4.29M
|
+$246K
|
+14,788
|
+4%
|
|
|
13
|
State Street
Boston,
Massachusetts
|
$3.61M
|
+$258K
|
+15,519
|
+5%
|
|
|
14
|
Northern Trust
Chicago,
Illinois
|
$1.69M
|
+$4.04K
|
+243
|
+0.2%
|
|
|
15
|
Woodline Partners
San Francisco,
California
|
$1.66M
|
-$6.13M
|
-368,064
|
-73%
|
|
|
16
|
|
$1.57M
|
+$431K
|
+25,874
|
+25%
|
|
|
17
|
Vident Investment Advisory
Alpharetta,
Georgia
|
$671K
|
-$33.8K
|
-2,031
|
-4%
|
|
|
18
|
Bank of New York Mellon
New York
|
$642K
|
-$6.89K
|
-414
|
-0.8%
|
|
|
19
|
DekaBank Deutsche Girozentrale
Frankfurt,
Germany
|
$574K
|
–
|
–
|
–
|
|
|
20
|
Nuveen
Charlotte,
North Carolina
|
$555K
|
-$247K
|
-14,814
|
-24%
|
|
|
21
|
Charles Schwab
San Francisco,
California
|
$549K
|
-$38.2K
|
-2,298
|
-5%
|
|
|
22
|
Millennium Management
New York
|
$413K
|
-$96.6K
|
-5,807
|
-15%
|
|
|
23
|
|
$405K
|
+$267K
|
+16,020
|
+92%
|
|
|
24
|
Swiss National Bank
Zurich,
Switzerland
|
$327K
|
+$449K
|
+27,000
|
New
|
|
|
25
|
RhumbLine Advisers
Boston,
Massachusetts
|
$325K
|
+$19.3K
|
+1,158
|
+5%
|
|
