|
1
|
RA Capital Management
Boston,
Massachusetts
|
$114M
|
–
|
–
|
–
|
|
|
2
|
Fidelity Investments
Boston,
Massachusetts
|
$73.8M
|
-$9.39M
|
-641,532
|
-10%
|
|
|
3
|
|
$37.4M
|
–
|
–
|
–
|
|
|
4
|
Citadel Advisors
Miami,
Florida
|
$24.4M
|
+$23.3K
|
+1,595
|
+0.1%
|
|
|
5
|
Janus Henderson Group
London,
|
$24.2M
|
-$1.79M
|
-122,253
|
-6%
|
|
|
6
|
BVF Inc
San Francisco,
California
|
$19.4M
|
–
|
–
|
–
|
|
|
7
|
EcoR1 Capital
San Francisco,
California
|
$18.7M
|
–
|
–
|
–
|
|
|
8
|
|
$14.5M
|
-$2.16M
|
-147,293
|
-12%
|
|
|
9
|
Vanguard Group
Malvern,
Pennsylvania
|
$9.94M
|
-$85.7K
|
-5,854
|
-0.8%
|
|
|
10
|
Adage Capital Partners
Boston,
Massachusetts
|
$9.23M
|
+$4.41M
|
+301,066
|
+75%
|
|
|
11
|
Woodline Partners
San Francisco,
California
|
$6.66M
|
+$1.54M
|
+105,183
|
+26%
|
|
|
12
|
5AM Venture Management
San Francisco,
California
|
$5.88M
|
–
|
–
|
–
|
|
|
13
|
Samsara BioCapital
Palo Alto,
California
|
$4.75M
|
–
|
–
|
–
|
|
|
14
|
Geode Capital Management
Boston,
Massachusetts
|
$4.47M
|
+$77.2K
|
+5,276
|
+2%
|
|
|
15
|
State Street
Boston,
Massachusetts
|
$3.73M
|
+$277K
|
+18,903
|
+7%
|
|
|
16
|
Northern Trust
Chicago,
Illinois
|
$1.84M
|
+$49.2K
|
+3,364
|
+2%
|
|
|
17
|
|
$1.37M
|
-$18.6K
|
-1,270
|
-1%
|
|
|
18
|
Nuveen
Charlotte,
North Carolina
|
$799K
|
-$178K
|
-12,160
|
-17%
|
|
|
19
|
Vident Investment Advisory
Alpharetta,
Georgia
|
$757K
|
+$842K
|
+57,514
|
New
|
|
|
20
|
Bank of New York Mellon
New York
|
$705K
|
+$49.9K
|
+3,412
|
+7%
|
|
|
21
|
DekaBank Deutsche Girozentrale
Frankfurt,
Germany
|
$668K
|
–
|
–
|
–
|
|
|
22
|
Charles Schwab
San Francisco,
California
|
$628K
|
+$16.5K
|
+1,127
|
+2%
|
|
|
23
|
Millennium Management
New York
|
$526K
|
+$584K
|
+39,910
|
New
|
|
|
24
|
|
$416K
|
+$462K
|
+31,563
|
New
|
|
|
25
|
RhumbLine Advisers
Boston,
Massachusetts
|
$338K
|
+$1.63K
|
+111
|
+0.4%
|
|
