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John Overdeck’s Spero Therapeutics SPRO Stock Holding History

John Overdeck’s Portfolio SPRO Stock Details SPRO Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q2 		$846K Sell
382,814
-502,817
-57% -$1.32M ﹤0.01% 3736
2026
Q1 		$2.07M Buy
885,631
+513,061
+138% +$1.22M ﹤0.01% 2732
2025
Q4 		$868K Buy
372,570
+323,171
+654% +$750K ﹤0.01% 3025
2025
Q3 		$92.9K Buy
+49,399
New +$109K ﹤0.01% 3481
2023
Q4 		– Sell
-17,023
Closed -$20.6K – 3366
2023
Q3 		$20.6K Sell
17,023
-67,512
-80% -$93.5K ﹤0.01% 2870
2023
Q2 		$123K Buy
84,535
+52,435
+163% +$89.8K ﹤0.01% 2727
2023
Q1 		$46.5K Sell
32,100
-7,695
-19% -$12.9K ﹤0.01% 2768
2022
Q4 		$68.8K Buy
+39,795
New +$74.3K ﹤0.01% 2557
2022
Q3 		– Sell
-437,280
Closed -$324K – 2804
2022
Q2 		$324K Buy
437,280
+358,372
+454% +$1.04M ﹤0.01% 2002
2022
Q1 		$686K Buy
+78,908
New +$808K ﹤0.01% 1873
2021
Q1 		– Sell
-43,373
Closed -$841K – 4223
2020
Q4 		$841K Buy
+43,373
New +$676K ﹤0.01% 2134
2020
Q3 		– Sell
-28,150
Closed -$381K – 3518
2020
Q2 		$381K Buy
+28,150
New +$316K ﹤0.01% 2205
2020
Q1 		– Sell
-18,828
Closed -$181K – 3775
2019
Q4 		$181K Buy
+18,828
New +$203K ﹤0.01% 3443
2019
Q1 		– Sell
-27,454
Closed -$169K – 3439
2018
Q4 		$169K Buy
+27,454
New +$222K ﹤0.01% 2744

Other funds holding SPRO

GP
GSK plc London $602M AUM
P
Pfizer New York $170M AUM 191.09% 1-Year Est. Return
Vanguard Capital Management
Vanguard Capital Management Malvern, Pennsylvania $4.68T AUM
Renaissance Technologies
Renaissance Technologies New York $72.6B AUM 54.88% 1-Year Est. Return
AI
Alphabet Inc Mountain View, California $99.1B AUM 124.46% 1-Year Est. Return
Susquehanna International Group
Susquehanna International Group Bala Cynwyd, Pennsylvania $1.28T AUM 58.89% 1-Year Est. Return
BlackRock
BlackRock New York $6.73T AUM 46.02% 1-Year Est. Return
Geode Capital Management
Geode Capital Management Boston, Massachusetts $1.88T AUM 44.46% 1-Year Est. Return
Raymond James Financial
Raymond James Financial St Petersburg, Florida $369B AUM 28.27% 1-Year Est. Return
Arrowstreet Capital
Arrowstreet Capital Boston, Massachusetts $225B AUM 49.49% 1-Year Est. Return

John Overdeck's SPRO Position: Q2 2026 in Review

John Overdeck reduced its Spero Therapeutics (SPRO) stake by 57% in Q2 2026, selling an estimated $1.32M and leaving 382,814 shares worth $846K. The position accounts for ﹤0.01% of the portfolio, ranked #3736.

John Overdeck first reported a position in SPRO in Q4 2018 and has held it in 14 quarters since. The position peaked at $2.07M in Q1 2026. 60 funds tracked by Wall St. Rank hold SPRO as of Q2 2026.

  • John Overdeck held 382,814 shares of Spero Therapeutics worth $846K as of Q2 2026.
  • John Overdeck sold 502,817 Spero Therapeutics shares in Q2 2026, an estimated $1.32M.
  • Spero Therapeutics made up ﹤0.01% of John Overdeck's portfolio in Q2 2026, its #3736 holding.
  • John Overdeck first reported a position in Spero Therapeutics in Q4 2018 and has held it in 14 quarters since.
  • John Overdeck's Spero Therapeutics position peaked at $2.07M in Q1 2026.
  • 60 funds tracked by Wall St. Rank held Spero Therapeutics as of Q2 2026.

Based on Two Sigma Investments's 13F filing for Q2 2026, filed 14 Aug 2026.