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SPDR S&P Biotech ETF
XBI

Overview Fund Activity

611 hedge funds and large institutions have $9.72B invested in SPDR S&P Biotech ETF in 2025 Q2 according to their latest regulatory filings, with 54 funds opening new positions, 159 increasing their positions, 268 reducing their positions, and 102 closing their positions.

Holders
611
Holders Change
-61
Holders Change %
-9.08%
% of All Funds
8.21%
Holding in Top 10
15
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.2%
New
54
Increased
159
Reduced
268
Closed
102
Calls
$1.14B
Puts
$1.97B
Net Calls
-$834M
Net Calls Change
+$252M

Top Buyers

1
Goldman Sachs
1
Goldman Sachs
New York
$1.5B
2
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
2
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
Ontario, Canada
$1.01B
3
Citigroup
3
Citigroup
New York
$1.06B
4
Wells Fargo
4
Wells Fargo
California
$243M
5
JFG
5
Jefferies Financial Group
New York
$119M

Top Sellers

1
DFG
1
Demars Financial Group
Washington
$247K
2
UBS Group
2
UBS Group
Switzerland
$341M
3
BNP Paribas Financial Markets
3
BNP Paribas Financial Markets
France
$631M
4
HIIFS
4
Harel Insurance Investments & Financial Services
Israel
$0
5
Squarepoint
5
Squarepoint
New York
$39.2M
Name Market Value Shares Shares
Change 		Shares
Change %
Corient Private Wealth
76
Corient Private Wealth
Florida
$7.41M 89,396 +31,817 +55%
TAM
77
Tocqueville Asset Management
New York
$7.05M 84,986 -10,244 -11%
Brown Advisory
78
Brown Advisory
Maryland
$7.02M 84,592 -207,209 -71%
AI
79
Atom Investors
Texas
$6.97M 84,064 +21,580 +35%
Kovitz Investment Group Partners
80
Kovitz Investment Group Partners
Illinois
$6.86M 82,733 +11,570 +16%
CGA
81
Crescent Grove Advisors
Illinois
$6.61M 79,675 -4,440 -5%
CCM
82
Chiron Capital Management
Florida
$6.58M 79,338 -4,557 -5%
LJAC
83
L.J. Altfest & Co
New York
$6.35M 76,595 +49,309 +181%
WM
84
WS Management
Florida
$6.34M 76,457 – –
HighTower Advisors
85
HighTower Advisors
Illinois
$6.32M 76,190 -10,837 -12%
MAM
86
Marotta Asset Management
Virginia
$6.2M 74,706 +12,776 +21%
Wolverine Trading
87
Wolverine Trading
Illinois
$6.13M 73,843 +70,243 +1,951%
Tudor Investment Corp
88
Tudor Investment Corp
Connecticut
$6.03M 72,687 -74,404 -51%
XT
89
XTX Topco
Cayman Islands
$5.84M 70,419 +70,419 New
Fifth Third Bancorp
90
Fifth Third Bancorp
Ohio
$5.8M 69,944 -22,252 -24%
RFM
91
Royal Fund Management
Florida
$5.6M 67,521 +4,208 +7%
OC
92
Oppenheimer & Co
New York
$5.54M 66,776 -2,740 -4%
MMA
93
Mizuho Markets Americas
New York
$5.35M 64,470 +12,820 +25%
Envestnet Asset Management
94
Envestnet Asset Management
Illinois
$5.17M 62,354 -56,410 -47%
D.E. Shaw & Co
95
D.E. Shaw & Co
New York
$5.15M 62,064 -181,427 -75%
ONB
96
Old National Bancorp
Indiana
$5.12M 61,755 +56,471 +1,069%
NSLI
97
Nan Shan Life Insurance
Taiwan
$5.1M 61,464 -3,400 -5%
SB
98
SIG Brokerage
New York
$4.98M 60,067 +44,507 +286%
BL
99
BCWM LLC
Kansas
$4.78M 57,663 +13,291 +30%
Walleye Trading
100
Walleye Trading
New York
$4.63M 55,868 -20,972 -27%
2 3
4
5 6