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SPDR S&P Biotech ETF
XBI

Overview Fund Activity

611 hedge funds and large institutions have $9.72B invested in SPDR S&P Biotech ETF in 2025 Q2 according to their latest regulatory filings, with 54 funds opening new positions, 159 increasing their positions, 268 reducing their positions, and 102 closing their positions.

Holders
611
Holders Change
-61
Holders Change %
-9.08%
% of All Funds
8.21%
Holding in Top 10
15
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.2%
New
54
Increased
159
Reduced
268
Closed
102
Calls
$1.14B
Puts
$1.97B
Net Calls
-$834M
Net Calls Change
+$252M

Top Buyers

1
Goldman Sachs
1
Goldman Sachs
New York
$1.5B
2
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
2
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
Ontario, Canada
$1.01B
3
Citigroup
3
Citigroup
New York
$1.06B
4
Wells Fargo
4
Wells Fargo
California
$243M
5
JFG
5
Jefferies Financial Group
New York
$119M

Top Sellers

1
DFG
1
Demars Financial Group
Washington
$247K
2
UBS Group
2
UBS Group
Switzerland
$341M
3
BNP Paribas Financial Markets
3
BNP Paribas Financial Markets
France
$631M
4
HIIFS
4
Harel Insurance Investments & Financial Services
Israel
$0
5
Squarepoint
5
Squarepoint
New York
$39.2M
Name Market Value Shares Shares
Change 		Shares
Change %
Goldman Sachs
1
Goldman Sachs
New York
$1.5B 18,096,835 +4,997,277 +38%
Citigroup
2
Citigroup
New York
$1.06B 12,753,740 +2,275,774 +22%
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
3
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
Ontario, Canada
$1.01B 12,136,000 +3,650,000 +43%
Morgan Stanley
4
Morgan Stanley
New York
$947M 11,416,616 +504,492 +5%
JPMorgan Chase & Co
5
JPMorgan Chase & Co
New York
$882M 10,638,105 +268,399 +3%
BNP Paribas Financial Markets
6
BNP Paribas Financial Markets
France
$631M 7,610,581 -2,490,899 -25%
Bank of America
7
Bank of America
North Carolina
$552M 6,652,849 +188,267 +3%
UBS Group
8
UBS Group
Switzerland
$341M 4,117,555 -3,083,227 -43%
Wells Fargo
9
Wells Fargo
California
$243M 2,926,242 +745,172 +34%
Canada Pension Plan Investment Board
10
Canada Pension Plan Investment Board
Ontario, Canada
$146M 1,758,000 – –
MASUI
11
MIRAE ASSET SECURITIES (USA) INC.
New York
$124M 1,500,000 – –
Bessemer Group
12
Bessemer Group
New Jersey
$124M 1,494,666 +62,600 +4%
JFG
13
Jefferies Financial Group
New York
$119M 1,431,879 +636,869 +80%
Jane Street
14
Jane Street
New York
$106M 1,276,089 -193,580 -13%
Ameriprise
15
Ameriprise
Minnesota
$72.5M 872,796 +481,408 +123%
ERSOT
16
Employees Retirement System of Texas
Texas
$70.8M 853,372 -13,800 -2%
MIFH
17
Migdal Insurance & Financial Holdings
Israel
$62.2M 750,000 -300,000 -29%
ClearBridge Investments
18
ClearBridge Investments
New York
$61.1M 736,279 -78,494 -10%
HSBC Holdings
19
HSBC Holdings
United Kingdom
$58.9M 710,755 -108,512 -13%
LPL Financial
20
LPL Financial
California
$50.2M 605,035 -15,636 -3%
GF
21
Greenhouse Funds
Maryland
$48.1M 579,667 +315,422 +119%
IL
22
Investure LLC
Virginia
$46.6M 561,600 – –
Barclays
23
Barclays
United Kingdom
$42.9M 517,208 +351,361 +212%
N
24
Natixis
France
$41.5M 500,000 – –
Raymond James Financial
25
Raymond James Financial
Florida
$41.4M 499,439 -43,701 -8%
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