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SPDR S&P Biotech ETF
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Overview Fund Activity

699 hedge funds and large institutions have $7.06B invested in SPDR S&P Biotech ETF in 2022 Q1 according to their latest regulatory filings, with 123 funds opening new positions, 242 increasing their positions, 185 reducing their positions, and 112 closing their positions.

Holders
699
Holders Change
+1
Holders Change %
+0.14%
% of All Funds
11.06%
Holding in Top 10
20
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.32%
New
123
Increased
242
Reduced
185
Closed
112
Calls
$2.67B
Puts
$2.59B
Net Calls
+$79M
Net Calls Change
+$799M

Top Buyers

1
Morgan Stanley
1
Morgan Stanley
New York
$896M
2
BNP Paribas Financial Markets
2
BNP Paribas Financial Markets
France
$394M
3
MCMC
3
Matrix Capital Management Company
New Hampshire
$189M
4
ACA
4
Avoro Capital Advisors
New York
$274M
5
Bank of America
5
Bank of America
North Carolina
$549M

Top Sellers

1
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
1
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
Ontario, Canada
$69.2M
2
Jane Street
2
Jane Street
New York
$6.45M
3
Goldman Sachs
3
Goldman Sachs
New York
$512M
4
Bank of Nova Scotia
4
Bank of Nova Scotia
Ontario, Canada
$3.64M
5
BC
5
Boxer Capital
California
$62.9M
Name Market Value Shares Shares
Change 		Shares
Change %
Morgan Stanley
1
Morgan Stanley
New York
$896M 9,968,210 +6,908,170 +226%
Bank of America
2
Bank of America
North Carolina
$549M 6,111,848 +1,743,954 +40%
Goldman Sachs
3
Goldman Sachs
New York
$512M 5,701,763 -2,381,440 -29%
BNP Paribas Financial Markets
4
BNP Paribas Financial Markets
France
$394M 4,386,012 +3,254,587 +288%
Citigroup
5
Citigroup
New York
$363M 4,039,027 +398,170 +11%
Toronto Dominion Bank
6
Toronto Dominion Bank
Ontario, Canada
$278M 3,093,885 -150 -0%
ACA
7
Avoro Capital Advisors
New York
$274M 3,050,000 +2,000,000 +190%
MCMC
8
Matrix Capital Management Company
New Hampshire
$189M 2,100,000 +2,100,000 New
UBS Group
9
UBS Group
Switzerland
$188M 2,092,737 -462,515 -18%
CI
10
Clal Insurance
Israel
$182M 2,030,000 +1,182,000 +139%
Barclays
11
Barclays
United Kingdom
$131M 1,452,640 -485,399 -25%
Canada Pension Plan Investment Board
12
Canada Pension Plan Investment Board
Ontario, Canada
$108M 1,200,000 – –
AssetMark Inc
13
AssetMark Inc
California
$89.4M 994,774 +994,761 +7,652,008%
Wells Fargo
14
Wells Fargo
California
$81.9M 911,640 +96,847 +12%
Millennium Management
15
Millennium Management
New York
$75.8M 843,514 +313,186 +59%
PF
16
Phoenix Financial
Israel
$71.9M 799,505 – –
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
17
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
Ontario, Canada
$69.2M 770,000 -4,535,000 -85%
Bank Julius Baer & Co
18
Bank Julius Baer & Co
Switzerland
$69M 767,464 +38,654 +5%
JG
19
Jefferies Group
New York
$65.5M 729,017 +665,200 +1,042%
Northwestern Mutual Wealth Management
20
Northwestern Mutual Wealth Management
Wisconsin
$65.1M 724,403 +688,740 +1,931%
BC
21
Boxer Capital
California
$62.9M 700,000 -1,500,000 -68%
Susquehanna International Group
22
Susquehanna International Group
Pennsylvania
$59.1M 657,358 +596,465 +980%
LP
23
LMR Partners
United Kingdom
$58.3M 648,256 +514,631 +385%
Twin Tree Management
24
Twin Tree Management
Texas
$56.1M 623,806 +580,845 +1,352%
Royal Bank of Canada
25
Royal Bank of Canada
Ontario, Canada
$55.5M 617,397 +65,463 +12%
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