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SPDR S&P Biotech ETF
XBI

Overview Fund Activity

671 hedge funds and large institutions have $9.23B invested in SPDR S&P Biotech ETF in 2025 Q1 according to their latest regulatory filings, with 72 funds opening new positions, 176 increasing their positions, 269 reducing their positions, and 120 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
671
Holders Change
-60
Holders Change %
-8.21%
% of All Funds
9.11%
Holding in Top 10
15
Holding in Top 10 Change
-1
Holding in Top 10 Change %
-6.25%
% of All Funds
0.2%
New
72
Increased
176
Reduced
269
Closed
120
Calls
$1.08B
Puts
$2.17B
Net Calls
-$1.09B
Net Calls Change
+$169M

Top Buyers

1
UBS Group
UBS Group
Switzerland
+$294M
2
Goldman Sachs
Goldman Sachs
New York
+$287M
3
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
Ontario, Canada
+$269M
4
JPMorgan Chase & Co
JPMorgan Chase & Co
New York
+$191M
5
MIFH
Migdal Insurance & Financial Holdings
Israel
+$85.2M

Top Sellers

1
Bank of America
Bank of America
North Carolina
-$167M
2
BNP Paribas Financial Markets
BNP Paribas Financial Markets
France
-$145M
3
BCM
BlueCrest Capital Management
Jersey
-$138M
4
RCM
RA Capital Management
Massachusetts
-$111M
5
Citadel Advisors
Citadel Advisors
Florida
-$61M
Name Holding Trade Value Shares
Change 		Shares
Change %
Goldman Sachs
1
Goldman Sachs
New York
$1.06B +$287M +3,544,529 +37%
Morgan Stanley
2
Morgan Stanley
New York
$885M +$60.2M +742,059 +7%
Citigroup
3
Citigroup
New York
$850M -$54.6M -673,629 -6%
JPMorgan Chase & Co
4
JPMorgan Chase & Co
New York
$841M +$191M +2,360,858 +29%
BNP Paribas Financial Markets
5
BNP Paribas Financial Markets
France
$819M -$145M -1,783,010 -15%
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
6
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
Ontario, Canada
$688M +$269M +3,321,000 +64%
UBS Group
7
UBS Group
Switzerland
$584M +$294M +3,622,240 +101%
Bank of America
8
Bank of America
North Carolina
$524M -$167M -2,053,479 -24%
Wells Fargo
9
Wells Fargo
California
$177M -$1.23M -15,191 -0.7%
Canada Pension Plan Investment Board
10
Canada Pension Plan Investment Board
Ontario, Canada
$143M – – –
MASUI
11
MIRAE ASSET SECURITIES (USA) INC.
New York
$122M – – –
Jane Street
12
Jane Street
New York
$119M +$12.5M +153,853 +12%
Bessemer Group
13
Bessemer Group
New Jersey
$116M +$4.48M +55,232 +4%
MIFH
14
Migdal Insurance & Financial Holdings
Israel
$85.2M +$85.2M +1,050,000 New
Squarepoint
15
Squarepoint
New York
$77.5M +$29.5M +363,277 +61%
ERSOT
16
Employees Retirement System of Texas
Texas
$70.3M -$819K -10,100 -1%
ClearBridge Investments
17
ClearBridge Investments
New York
$66.1M +$19.7M +243,109 +43%
HSBC Holdings
18
HSBC Holdings
United Kingdom
$65.4M -$21.8M -272,796 -25%
JFG
19
Jefferies Financial Group
New York
$64.5M +$14.9M +184,277 +30%
LPL Financial
20
LPL Financial
California
$50.3M -$1.71M -21,113 -3%
HIIFS
21
Harel Insurance Investments & Financial Services
Israel
$48.7M +$48.7M +600,000 New
IL
22
Investure LLC
Virginia
$45.5M – – –
Raymond James Financial
23
Raymond James Financial
Florida
$44M -$5.96M -73,433 -12%
N
24
Natixis
France
$40.3M +$40.3M +500,000 New
DFG
25
Demars Financial Group
Washington
$38.4M +$10.8K +874 +0%
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