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SPDR S&P Biotech ETF
XBI

Overview Fund Activity

611 hedge funds and large institutions have $9.72B invested in SPDR S&P Biotech ETF in 2025 Q2 according to their latest regulatory filings, with 54 funds opening new positions, 159 increasing their positions, 268 reducing their positions, and 102 closing their positions.

Holders
611
Holders Change
-61
Holders Change %
-9.08%
% of All Funds
8.21%
Holding in Top 10
15
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.2%
New
54
Increased
159
Reduced
268
Closed
102
Calls
$1.14B
Puts
$1.97B
Net Calls
-$834M
Net Calls Change
+$252M

Top Buyers

1
Goldman Sachs
1
Goldman Sachs
New York
$1.5B
2
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
2
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
Ontario, Canada
$1.01B
3
Citigroup
3
Citigroup
New York
$1.06B
4
Wells Fargo
4
Wells Fargo
California
$243M
5
JFG
5
Jefferies Financial Group
New York
$119M

Top Sellers

1
DFG
1
Demars Financial Group
Washington
$247K
2
UBS Group
2
UBS Group
Switzerland
$341M
3
BNP Paribas Financial Markets
3
BNP Paribas Financial Markets
France
$631M
4
HIIFS
4
Harel Insurance Investments & Financial Services
Israel
$0
5
Squarepoint
5
Squarepoint
New York
$39.2M
Name Market Value Shares Shares
Change 		Shares
Change %
Squarepoint
26
Squarepoint
New York
$39.2M 472,145 -483,482 -51%
Royal Bank of Canada
27
Royal Bank of Canada
Ontario, Canada
$37.6M 453,402 +61,986 +16%
CI
28
Clal Insurance
Israel
$35.5M 428,000 +174,000 +69%
DCM
29
DAFNA Capital Management
California
$34.5M 415,505 +11,000 +3%
MIH
30
Meitav Investment House
Israel
$33.2M 400,454 +383,040 +2,200%
SO
31
STRS Ohio
Ohio
$31.5M 379,900 +37,100 +11%
Twin Tree Management
32
Twin Tree Management
Texas
$30.5M 367,705 +41,909 +13%
Millennium Management
33
Millennium Management
New York
$26.5M 319,630 +127,235 +66%
SFS
34
Strategic Financial Services
New York
$23.3M 281,347 +18,778 +7%
Neuberger Berman Group
35
Neuberger Berman Group
New York
$20.9M 252,593 -3,903 -2%
SGH
36
Sivik Global Healthcare
Connecticut
$20.7M 250,000 – –
WT
37
Whittier Trust
California
$19.1M 230,769 -96,332 -29%
BlackRock
38
BlackRock
New York
$19.1M 230,505 +13,974 +6%
Balyasny Asset Management
39
Balyasny Asset Management
Illinois
$18M 217,407 -60,598 -22%
OAM
40
Oxford Asset Management
United Kingdom
$17.8M 214,274 +134,151 +167%
Stifel Financial
41
Stifel Financial
Missouri
$16.8M 202,900 +8,025 +4%
G
42
GenTrust
Florida
$15.7M 188,821 -851 -0.4%
OPCM
43
Osborne Partners Capital Management
California
$15.4M 185,852 +83,572 +82%
UCMOK
44
United Capital Management of KS
Kansas
$15.3M 184,347 +5,110 +3%
Rockefeller Capital Management
45
Rockefeller Capital Management
New York
$14.2M 170,754 -767 -0.4%
VU
46
Vanderbilt University
Tennessee
$13.2M 158,746 +158,746 New
Cetera Investment Advisers
47
Cetera Investment Advisers
Illinois
$13.1M 157,722 +3,392 +2%
WAM
48
Weatherly Asset Management
California
$13M 156,499 -651 -0.4%
RSCM
49
Rock Springs Capital Management
Maryland
$12.6M 151,750 +151,750 New
HCS
50
Himension Capital (Singapore)
Singapore
$12.6M 151,455 +151,455 New
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