DAFNA Capital Management’s State Street SPDR S&P Biotech ETF XBI Stock Holding History

DAFNA Capital Management’s Portfolio XBI Stock Details XBI Fund Activity

Bought

Maintained

Sold

Quarter	Market Value	Status	Shares	Change in Stake	Trade Value	Portfolio Weight	Portfolio Position
2026 Q2	$31.1M	Sell	196,505 -122,000	-38%	-$16.5M	5.93%	2
2026 Q1	$40.7M	Sell	318,505 -18,000	-5%	-$2.25M	9.25%	2
2025 Q4	$41M	Sell	336,505 -65,000	-16%	-$7.45M	9.53%	2
2025 Q3	$40.2M	Sell	401,505 -14,000	-3%	-$1.26M	9.94%	2
2025 Q2	$34.5M	Buy	415,505 +11,000	+3%	+$878K	9.51%	1
2025 Q1	$32.8M	Buy	404,505 +7,000	+2%	+$626K	9.3%	1
2024 Q4	$35.8M	Sell	397,505 -4,000	-1%	-$388K	9.1%	1
2024 Q3	$39.7M	Sell	401,505 -43,500	-10%	-$4.27M	9.37%	1
2024 Q2	$41.3M	Buy	445,005 +13,790	+3%	+$1.24M	9.86%	1
2024 Q1	$40.9M	Sell	431,215 -52,785	-11%	-$4.9M	9.31%	1
2023 Q4	$43.2M	Sell	484,000 -81,000	-14%	-$6.02M	10.36%	1
2023 Q3	$41.3M	Hold	565,000	–	–	12.83%	1
2023 Q2	$47M	Sell	565,000 -5,000	-0.9%	-$418K	12.85%	1
2023 Q1	$43.4M	Buy	570,000 +4,000	+0.7%	+$332K	13.02%	1
2022 Q4	$47M	Hold	566,000	–	–	13.23%	1
2022 Q3	$44.9M	Sell	566,000 -47,000	-8%	-$3.96M	12.07%	1
2022 Q2	$45.5M	Buy	613,000 +343,500	+127%	+$25.8M	12.41%	1
2022 Q1	$24.2M	Buy	+269,500	New	+$24.9M	6.31%	2

Other funds holding XBI

BNP Paribas Financial Markets Paris, France $289B AUM 60.46% 1-Year Est. Return

Goldman Sachs New York $1.15T AUM 47.82% 1-Year Est. Return

Citigroup New York $303B AUM 53.02% 1-Year Est. Return

Morgan Stanley New York $1.89T AUM 35.08% 1-Year Est. Return

Bank of America Charlotte, North Carolina $1.55T AUM 33.47% 1-Year Est. Return

Healthcare of Ontario Pension Plan (HOOPP) Trust Fund Toronto, Ontario, Canada $71.2B AUM 48.86% 1-Year Est. Return

Wells Fargo San Francisco, California $617B AUM 30.33% 1-Year Est. Return

UBS Group Zurich, Switzerland $786B AUM 40.34% 1-Year Est. Return

Barclays London, United Kingdom $521B AUM 51.41% 1-Year Est. Return

JFG

Jefferies Financial Group New York $15.2B AUM 55.75% 1-Year Est. Return

DAFNA Capital Management's XBI Position: Q2 2026 in Review

DAFNA Capital Management reduced its State Street SPDR S&P Biotech ETF (XBI) stake by 38% in Q2 2026, selling an estimated $16.5M and leaving 196,505 shares worth $31.1M. The position accounts for 5.93% of the portfolio, ranked #2.

DAFNA Capital Management first reported a position in XBI in Q1 2022 and has held it in 18 quarters since. The position peaked at $47M in Q2 2023. 932 funds tracked by Wall St. Rank hold XBI as of Q2 2026.

DAFNA Capital Management held 196,505 shares of State Street SPDR S&P Biotech ETF worth $31.1M as of Q2 2026.
DAFNA Capital Management sold 122,000 State Street SPDR S&P Biotech ETF shares in Q2 2026, an estimated $16.5M.
State Street SPDR S&P Biotech ETF made up 5.93% of DAFNA Capital Management's portfolio in Q2 2026, its #2 holding.
DAFNA Capital Management first reported a position in State Street SPDR S&P Biotech ETF in Q1 2022 and has held it in 18 quarters since.
DAFNA Capital Management's State Street SPDR S&P Biotech ETF position peaked at $47M in Q2 2023.
932 funds tracked by Wall St. Rank held State Street SPDR S&P Biotech ETF as of Q2 2026.

Based on DAFNA Capital Management's 13F filing for Q2 2026, filed 14 Aug 2026.