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SPDR S&P Biotech ETF
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Overview Fund Activity

611 hedge funds and large institutions have $9.72B invested in SPDR S&P Biotech ETF in 2025 Q2 according to their latest regulatory filings, with 54 funds opening new positions, 159 increasing their positions, 268 reducing their positions, and 102 closing their positions.

Holders
611
Holders Change
-61
Holders Change %
-9.08%
% of All Funds
8.21%
Holding in Top 10
15
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.2%
New
54
Increased
159
Reduced
268
Closed
102
Calls
$1.14B
Puts
$1.97B
Net Calls
-$834M
Net Calls Change
+$252M

Top Buyers

1
Goldman Sachs
1
Goldman Sachs
New York
$1.5B
2
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
2
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
Ontario, Canada
$1.01B
3
Citigroup
3
Citigroup
New York
$1.06B
4
Wells Fargo
4
Wells Fargo
California
$243M
5
JFG
5
Jefferies Financial Group
New York
$119M

Top Sellers

1
DFG
1
Demars Financial Group
Washington
$247K
2
UBS Group
2
UBS Group
Switzerland
$341M
3
BNP Paribas Financial Markets
3
BNP Paribas Financial Markets
France
$631M
4
HIIFS
4
Harel Insurance Investments & Financial Services
Israel
$0
5
Squarepoint
5
Squarepoint
New York
$39.2M
Name Market Value Shares Shares
Change 		Shares
Change %
SI
651
Shaker Investments
Ohio
– – -5,571 Closed
TAL
652
TIG Advisors LLC
New York
– – -5,275 Closed
ARC
653
Advisor Resource Council
Texas
– – -5,217 Closed
KA
654
Kercheville Advisors
Texas
– – -5,205 Closed
SA
655
Sicart Associates
New York
– – -5,103 Closed
OAC
656
OMERS Administration Corp
Ontario, Canada
– – -4,600 Closed
SW
657
Simplicity Wealth
New Jersey
– – -4,438 Closed
LWL
658
Leo Wealth LLC
Texas
– – -4,275 Closed
AWA
659
Alta Wealth Advisors
Massachusetts
– – -4,118 Closed
IIA
660
Integral Investment Advisors
California
– – -4,000 Closed
FAIM
661
Financial Advocates Investment Management
Washington
– – -3,767 Closed
SGCA
662
Steel Grove Capital Advisors
Tennessee
– – -3,572 Closed
Belvedere Trading
663
Belvedere Trading
Illinois
– – -3,379 Closed
PAS
664
Park Avenue Securities
New York
– – -3,309 Closed
FFS
665
Founders Financial Securities
Maryland
– – -3,264 Closed
TL
666
Tradewinds LLC
North Carolina
– – -3,146 Closed
WA
667
WBH Advisory
Maryland
– – -3,101 Closed
CAS
668
CTC Alternative Strategies
Illinois
– – -2,944 Closed
IA
669
Integrity Alliance
Iowa
– – -2,913 Closed
ESB
670
Essex Savings Bank
Connecticut
– – -2,888 Closed
SIC
671
Sterling Investment Counsel
New York
– – -2,862 Closed
BCM
672
Bourgeon Capital Management
Connecticut
– – -2,822 Closed
GL
673
Graypoint LLC
New York
– – -2,771 Closed
ACI
674
Alpha Cubed Investments
California
– – -2,690 Closed
IAS
675
Insigneo Advisory Services
Florida
– – -2,677 Closed
25 26
27
28 29