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SPDR S&P Biotech ETF
XBI

Overview Fund Activity

611 hedge funds and large institutions have $9.72B invested in SPDR S&P Biotech ETF in 2025 Q2 according to their latest regulatory filings, with 54 funds opening new positions, 159 increasing their positions, 268 reducing their positions, and 102 closing their positions.

Holders
611
Holders Change
-61
Holders Change %
-9.08%
% of All Funds
8.2%
Holding in Top 10
15
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.2%
New
54
Increased
159
Reduced
268
Closed
102
Calls
$1.14B
Puts
$1.97B
Net Calls
-$834M
Net Calls Change
+$252M

Top Buyers

1
Goldman Sachs
1
Goldman Sachs
New York
$1.5B
2
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
2
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
Ontario, Canada
$1.01B
3
Citigroup
3
Citigroup
New York
$1.06B
4
Wells Fargo
4
Wells Fargo
California
$243M
5
JFG
5
Jefferies Financial Group
New York
$119M

Top Sellers

1
DFG
1
Demars Financial Group
Washington
$247K
2
UBS Group
2
UBS Group
Switzerland
$341M
3
BNP Paribas Financial Markets
3
BNP Paribas Financial Markets
France
$631M
4
HIIFS
4
Harel Insurance Investments & Financial Services
Israel
$0
5
Squarepoint
5
Squarepoint
New York
$39.2M
Name Market Value Shares Shares
Change 		Shares
Change %
NRG
601
Nemes Rush Group
Michigan
$1.24K 15 – –
CWM
602
Copia Wealth Management
Oregon
$912 11 +11 New
MAS
603
MPWM Advisory Solutions
Georgia
$829 10 – –
MYIA
604
Mount Yale Investment Advisors
Colorado
$664 8 +8 New
CB
605
CNB Bank
Pennsylvania
$663 8 – –
1IA
606
1620 Investment Advisors
Massachusetts
$581 7 – –
SIS
607
Sound Income Strategies
Florida
$581 7 +7 New
EWA
608
EverSource Wealth Advisors
Alabama
$498 6 – –
GAG
609
Goodman Advisory Group
Massachusetts
$498 6 – –
BWL
610
Bogart Wealth LLC
Virginia
$498 6 – –
FHA
611
First Horizon Advisors
Tennessee
$497 6 -344 -98%
GWM
612
GSB Wealth Management
Connecticut
$357 4 – –
OSAM
613
O'Shaughnessy Asset Management
Connecticut
$83 1 -376 -100%
HIIFS
614
Harel Insurance Investments & Financial Services
Israel
– – -600,000 Closed
JSAM
615
J. Safra Asset Management
New York
– – -308,731 Closed
ECM
616
ExodusPoint Capital Management
New York
– – -284,457 Closed
Simplex Trading
617
Simplex Trading
Illinois
– – -241,039 Closed
VOYA Investment Management
618
VOYA Investment Management
Georgia
– – -227,917 Closed
Swedbank
619
Swedbank
Sweden
– – -170,643 Closed
NL
620
Nuveen LLC
North Carolina
– – -149,658 Closed
Hudson Bay Capital Management
621
Hudson Bay Capital Management
Connecticut
– – -135,318 Closed
Wellington Management Group
622
Wellington Management Group
Massachusetts
– – -101,946 Closed
CM
623
Caption Management
Oklahoma
– – -97,473 Closed
APM
624
Avidity Partners Management
Texas
– – -94,000 Closed
Janus Henderson Group
625
Janus Henderson Group
United Kingdom
– – -88,839 Closed
23 24
25
26 27