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SPDR S&P Biotech ETF
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Overview Fund Activity

611 hedge funds and large institutions have $9.72B invested in SPDR S&P Biotech ETF in 2025 Q2 according to their latest regulatory filings, with 54 funds opening new positions, 159 increasing their positions, 268 reducing their positions, and 102 closing their positions.

Holders
611
Holders Change
-61
Holders Change %
-9.08%
% of All Funds
8.2%
Holding in Top 10
15
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.2%
New
54
Increased
159
Reduced
268
Closed
102
Calls
$1.14B
Puts
$1.97B
Net Calls
-$834M
Net Calls Change
+$252M

Top Buyers

1
Goldman Sachs
1
Goldman Sachs
New York
$1.5B
2
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
2
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
Ontario, Canada
$1.01B
3
Citigroup
3
Citigroup
New York
$1.06B
4
Wells Fargo
4
Wells Fargo
California
$243M
5
JFG
5
Jefferies Financial Group
New York
$119M

Top Sellers

1
DFG
1
Demars Financial Group
Washington
$247K
2
UBS Group
2
UBS Group
Switzerland
$341M
3
BNP Paribas Financial Markets
3
BNP Paribas Financial Markets
France
$631M
4
HIIFS
4
Harel Insurance Investments & Financial Services
Israel
$0
5
Squarepoint
5
Squarepoint
New York
$39.2M
Name Market Value Shares Shares
Change 		Shares
Change %
BIG
626
Boothe Investment Group
Delaware
– – -64,208 Closed
SRSA
627
S.R. Schill & Associates
Washington
– – -41,595 Closed
CWM
628
CMH Wealth Management
New Hampshire
– – -37,949 Closed
CCMG
629
Clark Capital Management Group
Pennsylvania
– – -35,267 Closed
MTWM
630
Masso Torrence Wealth Management
New Jersey
– – -33,437 Closed
VanEck Associates
631
VanEck Associates
New York
– – -33,244 Closed
HAC
632
Harbor Advisory Corp
New Hampshire
– – -29,384 Closed
APF
633
Alaska Permanent Fund
Alaska
– – -25,418 Closed
AFA
634
Arlington Financial Advisors
California
– – -22,685 Closed
MMRF
635
Michelson Medical Research Foundation
California
– – -19,300 Closed
GS
636
GWN Securities
Florida
– – -17,846 Closed
PCP
637
Proficio Capital Partners
Massachusetts
– – -17,783 Closed
DWM
638
Denver Wealth Management
Colorado
– – -17,096 Closed
UM
639
Ulysses Management
New York
– – -15,000 Closed
PA
640
PFG Advisors
Arizona
– – -14,382 Closed
MCP
641
Militia Capital Partners
Nevada
– – -13,864 Closed
Bank of Nova Scotia
642
Bank of Nova Scotia
Ontario, Canada
– – -9,189 Closed
LP
643
LMR Partners
United Kingdom
– – -8,692 Closed
WIA
644
World Investment Advisors
California
– – -8,264 Closed
KIA
645
Knollwood Investment Advisory
Maryland
– – -8,173 Closed
TFF
646
The Family Firm
Maryland
– – -6,797 Closed
MCCA
647
Mill Creek Capital Advisors
Pennsylvania
– – -6,767 Closed
CGL
648
Clarius Group LLC
Washington
– – -6,150 Closed
QC
649
Quantessence Capital
New York
– – -5,995 Closed
Group One Trading
650
Group One Trading
Illinois
– – -5,605 Closed
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