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SPDR S&P Biotech ETF
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Overview Fund Activity

611 hedge funds and large institutions have $9.72B invested in SPDR S&P Biotech ETF in 2025 Q2 according to their latest regulatory filings, with 54 funds opening new positions, 159 increasing their positions, 268 reducing their positions, and 102 closing their positions.

Holders
611
Holders Change
-61
Holders Change %
-9.08%
% of All Funds
8.21%
Holding in Top 10
15
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.2%
New
54
Increased
159
Reduced
268
Closed
102
Calls
$1.14B
Puts
$1.97B
Net Calls
-$834M
Net Calls Change
+$252M

Top Buyers

1
Goldman Sachs
1
Goldman Sachs
New York
$1.5B
2
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
2
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
Ontario, Canada
$1.01B
3
Citigroup
3
Citigroup
New York
$1.06B
4
Wells Fargo
4
Wells Fargo
California
$243M
5
JFG
5
Jefferies Financial Group
New York
$119M

Top Sellers

1
DFG
1
Demars Financial Group
Washington
$247K
2
UBS Group
2
UBS Group
Switzerland
$341M
3
BNP Paribas Financial Markets
3
BNP Paribas Financial Markets
France
$631M
4
HIIFS
4
Harel Insurance Investments & Financial Services
Israel
$0
5
Squarepoint
5
Squarepoint
New York
$39.2M
Name Market Value Shares Shares
Change 		Shares
Change %
EBA
676
Eagle Bay Advisors
New York
– – -2,655 Closed
WW
677
Waterfront Wealth
Kansas
– – -2,654 Closed
SIA
678
SeaBridge Investment Advisors
New Jersey
– – -2,626 Closed
WA
679
WP Advisors
California
– – -2,613 Closed
CAM
680
Covenant Asset Management
New Jersey
– – -2,559 Closed
SI
681
Sava Infond
Slovenia
– – -2,550 Closed
MF
682
Montis Financial
Massachusetts
– – -2,549 Closed
Prudential Financial
683
Prudential Financial
New Jersey
– – -2,495 Closed
FM
684
Family Management
New York
– – -2,064 Closed
RCA
685
Runnymede Capital Advisors
Ohio
– – -1,782 Closed
HWA
686
Heritage Wealth Advisors
Virginia
– – -1,577 Closed
SW
687
SVB Wealth
Massachusetts
– – -1,345 Closed
Nomura Asset Management
688
Nomura Asset Management
Japan
– – -1,011 Closed
CA
689
Continuum Advisory
Idaho
– – -945 Closed
CCM
690
Coldstream Capital Management
Washington
– – -743 Closed
GFPC
691
Global Financial Private Client
Florida
– – -718 Closed
CWM
692
Compass Wealth Management
Connecticut
– – -635 Closed
MA
693
Montag & Associates
Georgia
– – -600 Closed
BOJHT
694
Bank of Jackson Hole Trust
Wyoming
– – -475 Closed
PWA
695
Provenance Wealth Advisors
Florida
– – -328 Closed
BT
696
Banque Transatlantique
France
– – -320 Closed
GI
697
GAMMA Investing
California
– – -260 Closed
SC
698
SouthState Corp
Florida
– – -240 Closed
DPW
699
DiNuzzo Private Wealth
Pennsylvania
– – -200 Closed
SHIM
700
Stone House Investment Management
Pennsylvania
– – -150 Closed
26 27
28
29 30