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SPDR S&P Biotech ETF
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Overview Fund Activity

611 hedge funds and large institutions have $9.72B invested in SPDR S&P Biotech ETF in 2025 Q2 according to their latest regulatory filings, with 54 funds opening new positions, 159 increasing their positions, 268 reducing their positions, and 102 closing their positions.

Holders
611
Holders Change
-61
Holders Change %
-9.08%
% of All Funds
8.2%
Holding in Top 10
15
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.2%
New
54
Increased
159
Reduced
268
Closed
102
Calls
$1.14B
Puts
$1.97B
Net Calls
-$834M
Net Calls Change
+$252M

Top Buyers

1
Goldman Sachs
1
Goldman Sachs
New York
$1.5B
2
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
2
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
Ontario, Canada
$1.01B
3
Citigroup
3
Citigroup
New York
$1.06B
4
Wells Fargo
4
Wells Fargo
California
$243M
5
JFG
5
Jefferies Financial Group
New York
$119M

Top Sellers

1
DFG
1
Demars Financial Group
Washington
$247K
2
UBS Group
2
UBS Group
Switzerland
$341M
3
BNP Paribas Financial Markets
3
BNP Paribas Financial Markets
France
$631M
4
HIIFS
4
Harel Insurance Investments & Financial Services
Israel
$0
5
Squarepoint
5
Squarepoint
New York
$39.2M
Name Market Value Shares Shares
Change 		Shares
Change %
SFG
701
Stonebridge Financial Group
Pennsylvania
– – -100 Closed
RMP
702
Richards, Merrill & Peterson
Washington
– – -100 Closed
RAM
703
Riggs Asset Management
Pennsylvania
– – -98 Closed
Russell Investments Group
704
Russell Investments Group
United Kingdom
– – -88 Closed
LFG
705
Larson Financial Group
Missouri
– – -78 Closed
AFG
706
Albion Financial Group
Utah
– – -75 Closed
MEG
707
Millstone Evans Group
Colorado
– – -55 Closed
MG
708
Mather Group
Illinois
– – -48 Closed
CFD
709
Creative Financial Designs
Indiana
– – -29 Closed
FFA
710
Founders Financial Alliance
North Carolina
– – -26 Closed
AF
711
Atala Financial
California
– – -25 Closed
SIC
712
SJS Investment Consulting
Ohio
– – -22 Closed
PFBT
713
Parkside Financial Bank & Trust
Missouri
– – -12 Closed
CFS
714
CGC Financial Services
Oregon
– – -5 Closed
BCMLT
715
Beacon Capital Management LLC (Tennessee)
Tennessee
– – -5 Closed
O
716
OrbiMed
New York
– – – –
DP
717
Diadema Partners
New Jersey
– – – –
RCMNY
718
Rubric Capital Management (New York)
New York
– – – –
CC
719
Centiva Capital
New York
– – – –
SFM
720
Sphera Funds Management
Israel
– – – –
PL
721
Parkwood LLC
Ohio
– – – –
JGC
722
J. Goldman & Co
New York
– – – –
CCM
723
Cinctive Capital Management
New York
– – – –
PA
724
Perceptive Advisors
New York
– – – –
UOC
725
UBS O'Connor
Illinois
– – – –
26 27 28
29
30