UPB
Upstream Bio Inc
UPB
UPB
78 hedge funds and large institutions have $261M invested in Upstream Bio Inc in 2025 Q1 according to their latest regulatory filings, with 24 funds opening new positions, 11 increasing their positions, 25 reducing their positions, and 15 closing their positions.
New
Increased
Maintained
Reduced
Closed
more first-time investments, than exits
New positions opened: | Existing positions closed:
more funds holding
Funds holding: →
more ownership
Funds ownership: →
less funds holding in top 10
Funds holding in top 10: →
56% less repeat investments, than reductions
Existing positions increased: 11 | Existing positions reduced: 25
62% less capital invested
Capital invested by funds: $690M → $261M (-$429M)
Holders
78
Holding in Top 10
4
Calls
–
Puts
–
Top Buyers
| 1 | +$7.95M | |
| 2 | +$3.52M | |
| 3 | +$1.43M | |
| 4 |
SSA
Schonfeld Strategic Advisors
New York
|
+$1.09M |
| 5 |
VCIM
Velan Capital Investment Management
Alpharetta,
Georgia
|
+$655K |
Top Sellers
| 1 | -$4.95M | |
| 2 | -$2.96M | |
| 3 | -$1.65M | |
| 4 |
MAP
Moody Aldrich Partners
Marblehead,
Massachusetts
|
-$1.23M |
| 5 |
SB
Samsara BioCapital
Palo Alto,
California
|
-$918K |
