|
1
|
Frazier Life Sciences Management
Palo Alto,
California
|
$709M
|
+$83.2M
|
+884,563
|
+13%
|
|
|
2
|
Janus Henderson Group
London,
|
$642M
|
+$82.8M
|
+880,505
|
+15%
|
|
|
3
|
|
$355M
|
+$18.9M
|
+201,244
|
+6%
|
|
|
4
|
Vanguard Capital Management
Malvern,
Pennsylvania
|
$223M
|
+$227M
|
+2,414,776
|
New
|
|
|
5
|
Fidelity Investments
Boston,
Massachusetts
|
$182M
|
+$124M
|
+1,318,909
|
+204%
|
|
|
6
|
State Street
Boston,
Massachusetts
|
$180M
|
-$18.8M
|
-199,711
|
-9%
|
|
|
7
|
T. Rowe Price Associates
Baltimore,
Maryland
|
$159M
|
+$27.9M
|
+297,046
|
+21%
|
|
|
8
|
BVF Inc
San Francisco,
California
|
$146M
|
+$8.41M
|
+89,437
|
+6%
|
|
|
9
|
Vanguard Portfolio Management
Malvern,
Pennsylvania
|
$132M
|
+$135M
|
+1,432,083
|
New
|
|
|
10
|
Eventide Asset Management
Boston,
Massachusetts
|
$130M
|
-$64.4M
|
-684,711
|
-33%
|
|
|
11
|
Wellington Management Group
Boston,
Massachusetts
|
$123M
|
+$9.12M
|
+96,979
|
+8%
|
|
|
12
|
Novo Holdings A/S
Hellerup,
Denmark
|
$122M
|
+$5.74M
|
+60,972
|
+5%
|
|
|
13
|
Geode Capital Management
Boston,
Massachusetts
|
$116M
|
+$18.5M
|
+197,077
|
+19%
|
|
|
14
|
Tang Capital Management
San Diego,
California
|
$114M
|
–
|
–
|
–
|
|
|
15
|
TCG Crossover Management
Palo Alto,
California
|
$98.1M
|
+$94.1M
|
+1,000,000
|
+1,612%
|
|
|
16
|
Citadel Advisors
Miami,
Florida
|
$97.2M
|
+$19.9M
|
+211,828
|
+25%
|
|
|
17
|
BNP Paribas Financial Markets
Paris,
France
|
$84.2M
|
+$24M
|
+255,641
|
+39%
|
|
|
18
|
Rock Springs Capital Management
Baltimore,
Maryland
|
$74.9M
|
+$4.61M
|
+49,000
|
+6%
|
|
|
19
|
Two Sigma Investments
New York
|
$71.6M
|
+$36.3M
|
+386,299
|
+99%
|
|
|
20
|
Capital World Investors
Los Angeles,
California
|
$66.9M
|
+$68.1M
|
+724,415
|
New
|
|
|
21
|
Bank of America
Charlotte,
North Carolina
|
$66.7M
|
+$821K
|
+8,725
|
+1%
|
|
|
22
|
Franklin Resources
San Mateo,
California
|
$66M
|
+$6.03M
|
+64,089
|
+10%
|
|
|
23
|
ClearBridge Investments
New York
|
$62.1M
|
-$18.3M
|
-194,097
|
-22%
|
|
|
24
|
|
$61.2M
|
-$5.83M
|
-62,011
|
-9%
|
|
|
25
|
Paradigm Biocapital Advisors
New York
|
$57.7M
|
+$58.8M
|
+625,000
|
New
|
|
