|
1
|
Frazier Life Sciences Management
Palo Alto,
California
|
$537M
|
–
|
–
|
–
|
|
|
2
|
Janus Henderson Group
London,
|
$479M
|
+$76.6M
|
+1,067,722
|
+21%
|
|
|
3
|
|
$288M
|
+$3.08M
|
+42,852
|
+1%
|
|
|
4
|
Vanguard Group
Malvern,
Pennsylvania
|
$205M
|
+$3.64M
|
+50,720
|
+2%
|
|
|
5
|
State Street
Boston,
Massachusetts
|
$169M
|
+$57.2M
|
+797,088
|
+59%
|
|
|
6
|
Eventide Asset Management
Boston,
Massachusetts
|
$165M
|
-$30.8M
|
-428,981
|
-17%
|
|
|
7
|
BVF Inc
San Francisco,
California
|
$118M
|
–
|
–
|
–
|
|
|
8
|
T. Rowe Price Associates
Baltimore,
Maryland
|
$112M
|
+$9.84M
|
+137,087
|
+11%
|
|
|
9
|
Novo Holdings A/S
Hellerup,
Denmark
|
$99.8M
|
–
|
–
|
–
|
|
|
10
|
Wellington Management Group
Boston,
Massachusetts
|
$97.8M
|
+$32.1M
|
+447,141
|
+57%
|
|
|
11
|
Tang Capital Management
San Diego,
California
|
$97.6M
|
–
|
–
|
–
|
|
|
12
|
Geode Capital Management
Boston,
Massachusetts
|
$84M
|
+$3.8M
|
+52,904
|
+5%
|
|
|
13
|
|
$74.9M
|
+$1.77M
|
+24,652
|
+3%
|
|
|
14
|
ClearBridge Investments
New York
|
$68.4M
|
-$9.89M
|
-137,836
|
-14%
|
|
|
15
|
Citadel Advisors
Miami,
Florida
|
$66.4M
|
-$14.4M
|
-200,324
|
-19%
|
|
|
16
|
Polar Capital Holdings
London,
United Kingdom
|
$62.7M
|
-$1.93M
|
-26,910
|
-3%
|
|
|
17
|
Rock Springs Capital Management
Baltimore,
Maryland
|
$60.2M
|
+$83.8K
|
+1,168
|
+0.2%
|
|
|
18
|
|
$57.2M
|
+$19.6M
|
+273,479
|
+61%
|
|
|
19
|
Bank of America
Charlotte,
North Carolina
|
$56.4M
|
+$23.2M
|
+322,978
|
+83%
|
|
|
20
|
BNP Paribas Financial Markets
Paris,
France
|
$51.8M
|
+$3.93M
|
+54,705
|
+9%
|
|
|
21
|
Franklin Resources
San Mateo,
California
|
$51.4M
|
+$3.56M
|
+49,578
|
+8%
|
|
|
22
|
Fidelity Investments
Boston,
Massachusetts
|
$51.1M
|
+$448K
|
+6,248
|
+1%
|
|
|
23
|
Lord, Abbett & Co
Jersey City,
New Jersey
|
$45.8M
|
-$5.88M
|
-81,957
|
-12%
|
|
|
24
|
Pictet Asset Management
Carouge,
Switzerland
|
$45.6M
|
+$2.58M
|
+35,997
|
+7%
|
|
|
25
|
Soleus Capital Management
Greenwich,
Connecticut
|
$45.3M
|
+$30.5M
|
+424,918
|
+286%
|
|
