|
1
|
Frazier Life Sciences Management
Palo Alto,
California
|
$899M
|
–
|
–
|
–
|
|
|
2
|
|
$692M
|
+$593M
|
+5,909,184
|
New
|
|
|
3
|
|
$514M
|
+$54.6M
|
+543,533
|
+14%
|
|
|
4
|
Fidelity Investments
Boston,
Massachusetts
|
$430M
|
+$171M
|
+1,704,939
|
+87%
|
|
|
5
|
T. Rowe Price Associates
Baltimore,
Maryland
|
$311M
|
+$94.2M
|
+938,186
|
+55%
|
|
|
6
|
Vanguard Portfolio Management
Malvern,
Pennsylvania
|
$278M
|
+$94.9M
|
+944,936
|
+66%
|
|
|
7
|
Vanguard Capital Management
Malvern,
Pennsylvania
|
$264M
|
-$16.1M
|
-160,667
|
-7%
|
|
|
8
|
State Street
Boston,
Massachusetts
|
$254M
|
+$22.7M
|
+226,408
|
+12%
|
|
|
9
|
William Blair Investment Management
Chicago,
Illinois
|
$164M
|
+$107M
|
+1,069,072
|
+318%
|
|
|
10
|
Geode Capital Management
Boston,
Massachusetts
|
$163M
|
+$13.4M
|
+133,905
|
+11%
|
|
|
11
|
|
$160M
|
+$108M
|
+1,078,848
|
+378%
|
|
|
12
|
Wellington Management Group
Boston,
Massachusetts
|
$153M
|
-$2.49M
|
-24,822
|
-2%
|
|
|
13
|
Eventide Asset Management
Boston,
Massachusetts
|
$146M
|
-$16.1M
|
-160,482
|
-11%
|
|
|
14
|
Tang Capital Management
San Diego,
California
|
$145M
|
–
|
–
|
–
|
|
|
15
|
Capital World Investors
Los Angeles,
California
|
$135M
|
+$43.1M
|
+429,065
|
+59%
|
|
|
16
|
Franklin Resources
San Mateo,
California
|
$135M
|
+$44M
|
+437,966
|
+61%
|
|
|
17
|
Novo Holdings A/S
Hellerup,
Denmark
|
$132M
|
-$20.1M
|
-200,000
|
-15%
|
|
|
18
|
TCG Crossover Management
Palo Alto,
California
|
$124M
|
–
|
–
|
–
|
|
|
19
|
BVF Inc
San Francisco,
California
|
$124M
|
-$53.1M
|
-528,700
|
-33%
|
|
|
20
|
Polar Capital Holdings
London,
United Kingdom
|
$99M
|
+$56.4M
|
+562,040
|
+198%
|
|
|
21
|
Rock Springs Capital Management
Baltimore,
Maryland
|
$93.4M
|
-$1.32M
|
-13,149
|
-2%
|
|
|
22
|
Nomura Asset Management International
Philadelphia,
Pennsylvania
|
$88M
|
+$34.8M
|
+346,723
|
+86%
|
|
|
23
|
Ameriprise
Minneapolis,
Minnesota
|
$85.1M
|
+$50.9M
|
+507,439
|
+231%
|
|
|
24
|
Two Sigma Investments
New York
|
$80.8M
|
-$8.49M
|
-84,523
|
-11%
|
|
|
25
|
Bank of New York Mellon
New York
|
$78.4M
|
+$8.58M
|
+85,451
|
+15%
|
|
