|
1
|
Frazier Life Sciences Management
Palo Alto,
California
|
$498M
|
–
|
–
|
–
|
|
|
2
|
Janus Henderson Group
London,
|
$367M
|
-$15.2M
|
-238,691
|
-5%
|
|
|
3
|
|
$264M
|
+$1.61M
|
+25,343
|
+0.7%
|
|
|
4
|
Vanguard Group
Malvern,
Pennsylvania
|
$187M
|
-$1.24M
|
-19,500
|
-0.8%
|
|
|
5
|
Eventide Asset Management
Boston,
Massachusetts
|
$185M
|
-$7.31M
|
-114,922
|
-4%
|
|
|
6
|
BVF Inc
San Francisco,
California
|
$110M
|
-$80.5M
|
-1,266,043
|
-46%
|
|
|
7
|
State Street
Boston,
Massachusetts
|
$98.7M
|
-$1.83M
|
-28,724
|
-2%
|
|
|
8
|
T. Rowe Price Associates
Baltimore,
Maryland
|
$94.1M
|
-$8.51M
|
-133,927
|
-9%
|
|
|
9
|
Novo Holdings A/S
Hellerup,
Denmark
|
$92.7M
|
-$15M
|
-236,027
|
-16%
|
|
|
10
|
Tang Capital Management
San Diego,
California
|
$90.6M
|
–
|
–
|
–
|
|
|
11
|
Citadel Advisors
Miami,
Florida
|
$76.3M
|
-$23.3M
|
-365,808
|
-26%
|
|
|
12
|
Geode Capital Management
Boston,
Massachusetts
|
$74.1M
|
-$1.25M
|
-19,594
|
-2%
|
|
|
13
|
ClearBridge Investments
New York
|
$73.6M
|
-$1.51M
|
-23,724
|
-2%
|
|
|
14
|
|
$67.7M
|
+$23.4M
|
+368,552
|
+66%
|
|
|
15
|
Polar Capital Holdings
London,
United Kingdom
|
$60.2M
|
-$9.82M
|
-154,448
|
-16%
|
|
|
16
|
Wellington Management Group
Boston,
Massachusetts
|
$58M
|
+$42.7M
|
+672,118
|
+567%
|
|
|
17
|
Point72 Asset Management
Stamford,
Connecticut
|
$58M
|
+$33.8M
|
+531,809
|
+205%
|
|
|
18
|
Rock Springs Capital Management
Baltimore,
Maryland
|
$55.8M
|
-$3.63M
|
-57,080
|
-7%
|
|
|
19
|
|
$49.1M
|
+$6.6M
|
+103,823
|
+18%
|
|
|
20
|
Lord, Abbett & Co
Jersey City,
New Jersey
|
$48.5M
|
-$6.94M
|
-109,206
|
-14%
|
|
|
21
|
Fidelity Investments
Boston,
Massachusetts
|
$46.9M
|
+$36.9M
|
+580,777
|
+977%
|
|
|
22
|
Arrowstreet Capital
Boston,
Massachusetts
|
$44.9M
|
+$34.1M
|
+536,674
|
+709%
|
|
|
23
|
Nuveen
Charlotte,
North Carolina
|
$44.1M
|
+$726K
|
+11,413
|
+2%
|
|
|
24
|
Franklin Resources
San Mateo,
California
|
$44.1M
|
+$479K
|
+7,541
|
+1%
|
|
|
25
|
BNP Paribas Financial Markets
Paris,
France
|
$44.1M
|
+$7.6M
|
+119,609
|
+25%
|
|
