|
1
|
Frazier Life Sciences Management
Palo Alto,
California
|
$256M
|
+$2.99M
|
+75,000
|
+1%
|
|
|
2
|
Janus Henderson Group
London,
|
$175M
|
-$20.3M
|
-508,463
|
-10%
|
|
|
3
|
Eventide Asset Management
Boston,
Massachusetts
|
$134M
|
-$6.76M
|
-169,457
|
-5%
|
|
|
4
|
|
$131M
|
+$5.19M
|
+130,108
|
+4%
|
|
|
5
|
BVF Inc
San Francisco,
California
|
$120M
|
-$51.6M
|
-1,294,117
|
-30%
|
|
|
6
|
Vanguard Group
Malvern,
Pennsylvania
|
$97.3M
|
+$1.97M
|
+49,379
|
+2%
|
|
|
7
|
State Street
Boston,
Massachusetts
|
$70M
|
+$11.9M
|
+297,511
|
+20%
|
|
|
8
|
Rock Springs Capital Management
Baltimore,
Maryland
|
$61.6M
|
-$7.64M
|
-191,550
|
-11%
|
|
|
9
|
Novo Holdings A/S
Hellerup,
Denmark
|
$58.5M
|
–
|
–
|
–
|
|
|
10
|
Citadel Advisors
Miami,
Florida
|
$54.3M
|
-$7.75M
|
-194,215
|
-12%
|
|
|
11
|
Tang Capital Management
San Diego,
California
|
$50.2M
|
–
|
–
|
–
|
|
|
12
|
T. Rowe Price Associates
Baltimore,
Maryland
|
$50.1M
|
+$3.39M
|
+84,886
|
+7%
|
|
|
13
|
Geode Capital Management
Boston,
Massachusetts
|
$36.5M
|
+$1.16M
|
+29,017
|
+3%
|
|
|
14
|
Pictet Asset Management
Carouge,
Switzerland
|
$34.9M
|
+$821K
|
+20,577
|
+2%
|
|
|
15
|
ClearBridge Investments
New York
|
$34.7M
|
+$7.55M
|
+189,167
|
+27%
|
|
|
16
|
Lord, Abbett & Co
Jersey City,
New Jersey
|
$28.9M
|
+$29.6M
|
+741,368
|
New
|
|
|
17
|
Avidity Partners Management
Dallas,
Texas
|
$28.5M
|
–
|
–
|
–
|
|
|
18
|
Polar Capital Holdings
London,
United Kingdom
|
$26.3M
|
-$2.63M
|
-66,049
|
-9%
|
|
|
19
|
First Turn Management
Del Mar,
California
|
$25.3M
|
-$2.23M
|
-55,787
|
-8%
|
|
|
20
|
|
$24.9M
|
-$4.83M
|
-121,051
|
-16%
|
|
|
21
|
|
$24.4M
|
+$3.39M
|
+84,894
|
+16%
|
|
|
22
|
Franklin Resources
San Mateo,
California
|
$23.6M
|
-$13.9M
|
-348,914
|
-37%
|
|
|
23
|
Boone Capital Management
Atlanta,
Georgia
|
$21.2M
|
+$804K
|
+20,164
|
+4%
|
|
|
24
|
Candriam SCA
Strassen, Luxembourg,
Luxembourg
|
$19.8M
|
–
|
–
|
–
|
|
|
25
|
Loomis, Sayles & Company
Boston,
Massachusetts
|
$19.5M
|
+$19.9M
|
+499,316
|
New
|
|
