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LYRA

LYRA THERAPEUTICS INC
LYRA

Delisted

LYRA was delisted on the 16th of March, 2026.

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26 hedge funds and large institutions have $20.2M invested in LYRA THERAPEUTICS INC in 2022 Q1 according to their latest regulatory filings, with 2 funds opening new positions, 6 increasing their positions, 7 reducing their positions, and 9 closing their positions.

New
Increased
Maintained
Reduced
Closed

0.02% less ownership

Funds ownership: 0.79% → 0.77% (-0.02%)

10% less capital invested

Capital invested by funds: $22.4M → $20.2M (-$2.19M)

14% less repeat investments, than reductions

Existing positions increased: 6 | Existing positions reduced: 7

21% less funds holding

Funds holding: 33 → 26 (-7)

78% less first-time investments, than exits

New positions opened: 2 | Existing positions closed: 9

Holders
26
Holders Change
-7
Holders Change %
-21.21%
% of All Funds
0.41%
Holding in Top 10
–
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
–
New
2
Increased
6
Reduced
7
Closed
9
Calls
–
Puts
–
Net Calls
–
Net Calls Change
–

Top Buyers

Rank Fund Capital Flow
1
CC
Clearline Capital
New York
+$242K
2
IC
Ikarian Capital
Texas
+$122K
3
JP Morgan Chase
JP Morgan Chase
New York
+$30.3K
4
PVI
Pura Vida Investments
New York
+$14.5K
5
Geode Capital Management
Geode Capital Management
Massachusetts
+$6.37K

Top Sellers

Rank Fund Capital Flow
1
Millennium Management
Millennium Management
New York
-$177K
2
Two Sigma Advisers
Two Sigma Advisers
New York
-$161K
3
Renaissance Technologies
Renaissance Technologies
New York
-$152K
4
Two Sigma Investments
Two Sigma Investments
New York
-$77K
5
Citadel Advisors
Citadel Advisors
Florida
-$58K
Name Holding Trade Value Shares
Change 		Change in
Stake
PA
1
Perceptive Advisors
New York
$13M – – –
PVI
2
Pura Vida Investments
New York
$2.09M +$14.5K +66 +0.6%
IC
3
Ikarian Capital
Texas
$1.7M +$122K +556 +7%
Vanguard Group
4
Vanguard Group
Pennsylvania
$879K – – –
CC
5
Clearline Capital
New York
$482K +$242K +1,101 +85%
Millennium Management
6
Millennium Management
New York
$453K -$177K -805 -26%
Bank of America
7
Bank of America
North Carolina
$330K -$7.25K -33 -2%
BCM
8
Bridgeway Capital Management
Texas
$269K – – –
PCM
9
Pentwater Capital Management
Florida
$241K -$49.6K -226 -16%
Ensign Peak Advisors
10
Ensign Peak Advisors
Utah
$157K – – –
BFM
11
Boothbay Fund Management
New York
$155K – – –
Geode Capital Management
12
Geode Capital Management
Massachusetts
$150K +$6.37K +29 +4%
Two Sigma Advisers
13
Two Sigma Advisers
New York
$80K -$161K -734 -65%
BlackRock
14
BlackRock
New York
$77K +$3.29K +15 +4%
Renaissance Technologies
15
Renaissance Technologies
New York
$70K -$152K -690 -66%
Morgan Stanley
16
Morgan Stanley
New York
$33K -$5.93K -27 -14%
JP Morgan Chase
17
JP Morgan Chase
New York
$31K +$30.3K +138 +812%
CAM
18
Close Asset Management
United Kingdom
$30K – – –
WAM
19
Worth Asset Management
Texas
$3K +$2.86K +13 New
Osaic Holdings
20
Osaic Holdings
Arizona
$2K -$3.29K -15 -60%
LWANC
21
Laurel Wealth Advisors (North Carolina)
North Carolina
$2K – – –
US Bancorp
22
US Bancorp
Minnesota
$2K – – –
Wells Fargo
23
Wells Fargo
California
$2K – – –
TWC
24
TD Waterhouse Canada
Ontario, Canada
$830 – – –
Two Sigma Investments
25
Two Sigma Investments
New York
– -$77K -355 Closed
1
2

LYRA Hedge Fund Activity: Q1 2022 in Review

26 of the 6,341 institutional investors tracked by Wall St. Rank reported a position in LYRA THERAPEUTICS INC (LYRA) for Q1 2022, worth a combined $20.2M — down 9.8% from $22.4M a quarter earlier.

Sellers outnumbered buyers: 9 funds closed out of LYRA and 2 opened new positions — a net loss of 7 holders — while 7 trimmed existing stakes and 6 added.

The largest buyer was Clearline Capital, adding an estimated $242K. The largest seller was Millennium Management, cutting an estimated $177K.

  • 26 institutional investors held LYRA THERAPEUTICS INC (LYRA) as of Q1 2022, down from 33 in Q4 2021.
  • Funds reported $20.2M of LYRA THERAPEUTICS INC stock for Q1 2022, down 9.8% quarter-over-quarter.
  • 2 funds opened new LYRA THERAPEUTICS INC positions in Q1 2022 and 9 closed out, a net change of -7 holders.
  • The largest LYRA THERAPEUTICS INC buyer in Q1 2022 was Clearline Capital, an estimated $242K added.
  • The largest LYRA THERAPEUTICS INC seller in Q1 2022 was Millennium Management, an estimated $177K sold.

Based on aggregated 13F filings for Q1 2022.