Two Sigma Advisers
LYRA

Two Sigma Advisers’s LYRA THERAPEUTICS INC LYRA Stock Holding History

Two Sigma Advisers’s Portfolio LYRA Stock Details LYRA Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2025
Q2 		– Sell
-7,290
Closed -$46K – 2441
2025
Q1 		$46K Sell
7,290
-420
-5% -$3.93K ﹤0.01% 2324
2024
Q4 		$79.6K Sell
7,710
-1,496
-16% -$16.5K ﹤0.01% 2246
2024
Q3 		$118K Sell
9,206
-4,426
-32% -$65K ﹤0.01% 2149
2024
Q2 		$189K Buy
13,632
+10,754
+374% +$1.22M ﹤0.01% 2230
2024
Q1 		$895K Buy
2,878
+1,864
+184% +$497K ﹤0.01% 1634
2023
Q4 		$266K Buy
+1,014
New +$184K ﹤0.01% 2144
2023
Q2 		– Sell
-566
Closed -$56.9K – 2549
2023
Q1 		$56.9K Sell
566
-6
-1% -$744 ﹤0.01% 2438
2022
Q4 		$89.8K Sell
572
-284
-33% -$56.2K ﹤0.01% 2311
2022
Q3 		$214K Buy
856
+88
+11% +$26K ﹤0.01% 2178
2022
Q2 		$217K Buy
768
+368
+92% +$100K ﹤0.01% 2252
2022
Q1 		$80K Sell
400
-734
-65% -$161K ﹤0.01% 2534
2021
Q4 		$247K Sell
1,134
-26
-2% -$8.35K ﹤0.01% 2210
2021
Q3 		$529K Buy
1,160
+280
+32% +$106K ﹤0.01% 1908
2021
Q2 		$353K Buy
880
+251
+40% +$114K ﹤0.01% 2084
2021
Q1 		$364K Buy
+629
New +$393K ﹤0.01% 2146

Other funds holding LYRA

PA
Perceptive Advisors New York $5.12B AUM 314.02% 1-Year Est. Return
SM
Sabby Management Miami Beach, Florida $45.1M AUM 74.25% 1-Year Est. Return
Vanguard Group
Vanguard Group Malvern, Pennsylvania $6.9T AUM 27.45% 1-Year Est. Return
Bank of America
Bank of America Charlotte, North Carolina $1.37T AUM 24.88% 1-Year Est. Return
IC
Ikarian Capital Dallas, Texas $1.23B AUM 600.17% 1-Year Est. Return
Geode Capital Management
Geode Capital Management Boston, Massachusetts $1.61T AUM 30.72% 1-Year Est. Return
State of Wisconsin Investment Board
State of Wisconsin Investment Board Madison, Wisconsin $43.7B AUM 27.76% 1-Year Est. Return
Morgan Stanley
Morgan Stanley New York $1.66T AUM 25.57% 1-Year Est. Return
Fidelity Investments
Fidelity Investments Boston, Massachusetts $1.9T AUM 41.92% 1-Year Est. Return
BlackRock
BlackRock New York $6.73T AUM 46.02% 1-Year Est. Return

Two Sigma Advisers's LYRA Position: Q2 2025 in Review

Two Sigma Advisers sold out of LYRA THERAPEUTICS INC (LYRA) in Q2 2025, closing a stake of 7,290 shares — an estimated $46K sold.

Two Sigma Advisers first reported a position in LYRA in Q1 2021 and held it in 15 quarters. The position peaked at $895K in Q1 2024. 30 funds tracked by Wall St. Rank hold LYRA as of Q2 2025.

  • Two Sigma Advisers reported no remaining LYRA THERAPEUTICS INC position as of Q2 2025 after selling out during the quarter.
  • Two Sigma Advisers sold 7,290 LYRA THERAPEUTICS INC shares in Q2 2025, an estimated $46K.
  • Two Sigma Advisers first reported a position in LYRA THERAPEUTICS INC in Q1 2021 and held it in 15 quarters.
  • Two Sigma Advisers's LYRA THERAPEUTICS INC position peaked at $895K in Q1 2024.
  • 30 funds tracked by Wall St. Rank held LYRA THERAPEUTICS INC as of Q2 2025.

Based on Two Sigma Advisers's 13F filing for Q2 2025, filed 14 Aug 2025.