PA
LYRA

Perceptive Advisors’s LYRA THERAPEUTICS INC LYRA Stock Holding History

Perceptive Advisors’s Portfolio LYRA Stock Details LYRA Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2025
Q4 		– Sell
-229,382
Closed -$1.5M – 121
2025
Q3 		$1.5M Sell
229,382
-25,768
-10% -$189K 0.04% 84
2025
Q2 		$2.29M Sell
255,150
-1
-0% -$8 0.08% 71
2025
Q1 		$1.61M Hold
255,151
– – 0.06% 73
2024
Q4 		$2.63M Hold
255,151
– – 0.07% 83
2024
Q3 		$3.28M Hold
255,151
– – 0.07% 87
2024
Q2 		$3.53M Hold
255,151
– – 0.09% 86
2024
Q1 		$79.4M Hold
255,151
– – 1.39% 24
2023
Q4 		$66.8M Hold
255,151
– – 1.49% 21
2023
Q3 		$49.9M Hold
255,151
– – 1.66% 17
2023
Q2 		$52.4M Buy
255,151
+72,216
+39% +$10M 1.52% 18
2023
Q1 		$18.4M Hold
182,935
– – 0.54% 47
2022
Q4 		$28.7M Hold
182,935
– – 0.81% 38
2022
Q3 		$45.8M Hold
182,935
– – 1.33% 22
2022
Q2 		$51.7M Buy
182,935
+118,484
+184% +$32.3M 1.62% 13
2022
Q1 		$13M Hold
64,451
– – 0.26% 71
2021
Q4 		$14.1M Hold
64,451
– – 0.22% 77
2021
Q3 		$29.4M Hold
64,451
– – 0.43% 59
2021
Q2 		$25.9M Hold
64,451
– – 0.34% 73
2021
Q1 		$37.3M Hold
64,451
– – 0.47% 53
2020
Q4 		$36.7M Hold
64,451
– – 0.39% 56
2020
Q3 		$36M Hold
64,451
– – 0.53% 49
2020
Q2 		$36.5M Buy
+64,451
New +$47.1M 0.59% 40

Other funds holding LYRA

SM
Sabby Management Miami Beach, Florida $45.1M AUM 74.25% 1-Year Est. Return
IC
Ikarian Capital Dallas, Texas $1.23B AUM 600.17% 1-Year Est. Return
DS
DRW Securities Chicago, Illinois $7.21B AUM 20.54% 1-Year Est. Return
Geode Capital Management
Geode Capital Management Boston, Massachusetts $1.61T AUM 30.72% 1-Year Est. Return
AGP
Artia Global Partners Miami, Florida $499M AUM 186.05% 1-Year Est. Return
BlackRock
BlackRock New York $6.73T AUM 46.02% 1-Year Est. Return
TRCT
Tower Research Capital (TRC) New York $3.85B AUM 32.11% 1-Year Est. Return
Royal Bank of Canada
Royal Bank of Canada Toronto, Ontario, Canada $570B AUM 27.57% 1-Year Est. Return
UBS Group
UBS Group Zurich, Switzerland $666B AUM 30.12% 1-Year Est. Return
EWA
EverSource Wealth Advisors Birmingham, Alabama $2.97B AUM 28.72% 1-Year Est. Return

Perceptive Advisors's LYRA Position: Q4 2025 in Review

Perceptive Advisors sold out of LYRA THERAPEUTICS INC (LYRA) in Q4 2025, closing a stake of 229,382 shares — an estimated $1.5M sold.

Perceptive Advisors first reported a position in LYRA in Q2 2020 and held it in 22 quarters. The position peaked at $79.4M in Q1 2024. 23 funds tracked by Wall St. Rank hold LYRA as of Q4 2025.

  • Perceptive Advisors reported no remaining LYRA THERAPEUTICS INC position as of Q4 2025 after selling out during the quarter.
  • Perceptive Advisors sold 229,382 LYRA THERAPEUTICS INC shares in Q4 2025, an estimated $1.5M.
  • Perceptive Advisors first reported a position in LYRA THERAPEUTICS INC in Q2 2020 and held it in 22 quarters.
  • Perceptive Advisors's LYRA THERAPEUTICS INC position peaked at $79.4M in Q1 2024.
  • 23 funds tracked by Wall St. Rank held LYRA THERAPEUTICS INC as of Q4 2025.

Based on Perceptive Advisors's 13F filing for Q4 2025, filed 17 Feb 2026.