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LYRA

LYRA THERAPEUTICS INC
LYRA

Delisted

LYRA was delisted on the 16th of March, 2026.

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36 hedge funds and large institutions have $109M invested in LYRA THERAPEUTICS INC in 2022 Q2 according to their latest regulatory filings, with 14 funds opening new positions, 9 increasing their positions, 8 reducing their positions, and 4 closing their positions.

New
Increased
Maintained
Reduced
Closed

439% more capital invested

Capital invested by funds: $20.2M → $109M (+$88.7M)

250% more first-time investments, than exits

New positions opened: 14 | Existing positions closed: 4

38% more funds holding

Funds holding: 26 → 36 (+10)

13% more repeat investments, than reductions

Existing positions increased: 9 | Existing positions reduced: 8

0.44% more ownership

Funds ownership: 0.77% → 1.21% (+0.44%)

Holders
36
Holders Change
+10
Holders Change %
+38.46%
% of All Funds
0.61%
Holding in Top 10
1
Holding in Top 10 Change
+1
Holding in Top 10 Change %
% of All Funds
0.02%
New
14
Increased
9
Reduced
8
Closed
4
Calls
–
Puts
–
Net Calls
–
Net Calls Change
–

Top Buyers

Rank Fund Capital Flow
1
PA
Perceptive Advisors
New York
+$32.3M
2
NCM
Nantahala Capital Management
Connecticut
+$12.9M
3
PVI
Pura Vida Investments
New York
+$11.2M
4
SB
Samsara BioCapital
California
+$9.68M
5
VA
VR Adviser
New York
+$5.03M

Top Sellers

Rank Fund Capital Flow
1
IC
Ikarian Capital
Texas
-$408K
2
PCM
Pentwater Capital Management
Florida
-$241K
3
Millennium Management
Millennium Management
New York
-$131K
4
BCM
Bridgeway Capital Management
Texas
-$54.4K
5
JP Morgan Chase
JP Morgan Chase
New York
-$41.9K
Name Holding Trade Value Shares
Change 		Change in
Stake
PA
1
Perceptive Advisors
New York
$51.7M +$32.3M +118,484 +184%
PVI
2
Pura Vida Investments
New York
$14.6M +$11.2M +41,113 +395%
NCM
3
Nantahala Capital Management
Connecticut
$13.4M +$12.9M +47,393 New
SB
4
Samsara BioCapital
California
$10M +$9.68M +35,545 New
VA
5
VR Adviser
New York
$5.22M +$5.03M +18,483 New
Vanguard Group
6
Vanguard Group
Pennsylvania
$3.82M +$2.49M +9,138 +209%
SCM
7
Soleus Capital Management
Connecticut
$3.35M +$3.23M +11,848 New
IC
8
Ikarian Capital
Texas
$1.96M -$408K -1,500 -18%
Geode Capital Management
9
Geode Capital Management
Massachusetts
$680K +$452K +1,661 +222%
CC
10
Clearline Capital
New York
$673K -$4.08K -15 -0.6%
Bank of America
11
Bank of America
North Carolina
$551K +$83.3K +306 +19%
Millennium Management
12
Millennium Management
New York
$501K -$131K -480 -21%
CH
13
CVI Holdings
Delaware
$344K +$331K +1,216 New
BCM
14
Bridgeway Capital Management
Texas
$321K -$54.4K -200 -15%
Ensign Peak Advisors
15
Ensign Peak Advisors
Utah
$318K +$93.1K +342 +44%
BlackRock
16
BlackRock
New York
$235K +$123K +452 +119%
Renaissance Technologies
17
Renaissance Technologies
New York
$232K +$128K +470 +134%
BFM
18
Boothbay Fund Management
New York
$217K -$817 -3 -0.4%
Two Sigma Advisers
19
Two Sigma Advisers
New York
$217K +$100K +368 +92%
State Street
20
State Street
Massachusetts
$193K +$186K +685 New
Northern Trust
21
Northern Trust
Illinois
$169K +$163K +597 New
Two Sigma Investments
22
Two Sigma Investments
New York
$76K +$73.5K +270 New
Marshall Wace
23
Marshall Wace
United Kingdom
$74K +$70.5K +259 New
HWM
24
HighMark Wealth Management
Minnesota
$23K +$21.8K +80 New
UBS Group
25
UBS Group
Switzerland
$11K +$10.9K +40 New
1
2

LYRA Hedge Fund Activity: Q2 2022 in Review

36 of the 5,937 institutional investors tracked by Wall St. Rank reported a position in LYRA THERAPEUTICS INC (LYRA) for Q2 2022, worth a combined $109M — up 439% from $20.2M a quarter earlier.

Buyers outnumbered sellers: 14 funds opened new LYRA positions and 4 closed out — a net gain of 10 holders — while 9 added to existing stakes and 8 trimmed.

The largest buyer was Perceptive Advisors, adding an estimated $32.3M. The largest seller was Ikarian Capital, cutting an estimated $408K.

  • 36 institutional investors held LYRA THERAPEUTICS INC (LYRA) as of Q2 2022, up from 26 in Q1 2022.
  • Funds reported $109M of LYRA THERAPEUTICS INC stock for Q2 2022, up 439% quarter-over-quarter.
  • 14 funds opened new LYRA THERAPEUTICS INC positions in Q2 2022 and 4 closed out, a net change of +10 holders.
  • The largest LYRA THERAPEUTICS INC buyer in Q2 2022 was Perceptive Advisors, an estimated $32.3M added.
  • The largest LYRA THERAPEUTICS INC seller in Q2 2022 was Ikarian Capital, an estimated $408K sold.

Based on aggregated 13F filings for Q2 2022.