Two Sigma Investments
LYRA

Two Sigma Investments’s LYRA THERAPEUTICS INC LYRA Stock Holding History

Two Sigma Investments’s Portfolio LYRA Stock Details LYRA Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2025
Q2 		– Sell
-3,863
Closed -$24.4K – 3381
2025
Q1 		$24.4K Sell
3,863
-337
-8% -$3.15K ﹤0.01% 3090
2024
Q4 		$43.3K Sell
4,200
-1,451
-26% -$16K ﹤0.01% 3058
2024
Q3 		$72.6K Sell
5,651
-4,166
-42% -$61.2K ﹤0.01% 2931
2024
Q2 		$136K Buy
9,817
+6,142
+167% +$694K ﹤0.01% 2790
2024
Q1 		$1.14M Buy
3,675
+1,023
+39% +$273K ﹤0.01% 1871
2023
Q4 		$695K Buy
2,652
+2,324
+709% +$421K ﹤0.01% 2288
2023
Q3 		$64.2K Buy
+328
New +$58.7K ﹤0.01% 2792
2022
Q3 		– Sell
-270
Closed -$76K – 2669
2022
Q2 		$76K Buy
+270
New +$73.5K ﹤0.01% 2300
2022
Q1 		– Sell
-355
Closed -$77K – 3628
2021
Q4 		$77K Buy
355
+87
+32% +$27.9K ﹤0.01% 4103
2021
Q3 		$122K Sell
268
-210
-44% -$79.4K ﹤0.01% 4059
2021
Q2 		$192K Sell
478
-963
-67% -$439K ﹤0.01% 3793
2021
Q1 		$835K Buy
1,441
+991
+220% +$619K ﹤0.01% 2481
2020
Q4 		$257K Buy
+450
New +$254K ﹤0.01% 2974
2020
Q3 		– Sell
-412
Closed -$234K – 3362
2020
Q2 		$234K Buy
+412
New +$301K ﹤0.01% 2536

Other funds holding LYRA

PA
Perceptive Advisors New York $5.12B AUM 314.02% 1-Year Est. Return
SM
Sabby Management Miami Beach, Florida $45.1M AUM 74.25% 1-Year Est. Return
Vanguard Group
Vanguard Group Malvern, Pennsylvania $6.9T AUM 27.45% 1-Year Est. Return
Bank of America
Bank of America Charlotte, North Carolina $1.37T AUM 24.88% 1-Year Est. Return
IC
Ikarian Capital Dallas, Texas $1.23B AUM 600.17% 1-Year Est. Return
Geode Capital Management
Geode Capital Management Boston, Massachusetts $1.61T AUM 30.72% 1-Year Est. Return
State of Wisconsin Investment Board
State of Wisconsin Investment Board Madison, Wisconsin $43.7B AUM 27.76% 1-Year Est. Return
Morgan Stanley
Morgan Stanley New York $1.66T AUM 25.57% 1-Year Est. Return
Fidelity Investments
Fidelity Investments Boston, Massachusetts $1.9T AUM 41.92% 1-Year Est. Return
BlackRock
BlackRock New York $6.73T AUM 46.02% 1-Year Est. Return

Two Sigma Investments's LYRA Position: Q2 2025 in Review

Two Sigma Investments sold out of LYRA THERAPEUTICS INC (LYRA) in Q2 2025, closing a stake of 3,863 shares — an estimated $24.4K sold.

Two Sigma Investments first reported a position in LYRA in Q2 2020 and held it in 14 quarters. The position peaked at $1.14M in Q1 2024. 30 funds tracked by Wall St. Rank hold LYRA as of Q2 2025.

  • Two Sigma Investments reported no remaining LYRA THERAPEUTICS INC position as of Q2 2025 after selling out during the quarter.
  • Two Sigma Investments sold 3,863 LYRA THERAPEUTICS INC shares in Q2 2025, an estimated $24.4K.
  • Two Sigma Investments first reported a position in LYRA THERAPEUTICS INC in Q2 2020 and held it in 14 quarters.
  • Two Sigma Investments's LYRA THERAPEUTICS INC position peaked at $1.14M in Q1 2024.
  • 30 funds tracked by Wall St. Rank held LYRA THERAPEUTICS INC as of Q2 2025.

Based on Two Sigma Investments's 13F filing for Q2 2025, filed 14 Aug 2025.