|
1
|
Baker Bros. Advisors
New York
|
$123M
|
+$128K
|
+15,000
|
+0.1%
|
|
|
2
|
Janus Henderson Group
London,
|
$99.8M
|
-$386K
|
-45,113
|
-0.4%
|
|
|
3
|
|
$70.8M
|
-$1.3M
|
-152,061
|
-2%
|
|
|
4
|
RA Capital Management
Boston,
Massachusetts
|
$70.5M
|
-$17.1M
|
-2,000,366
|
-19%
|
|
|
5
|
Deerfield Management
New York
|
$53.2M
|
-$3.2M
|
-373,223
|
-5%
|
|
|
6
|
Vanguard Group
Malvern,
Pennsylvania
|
$49.2M
|
+$1.47M
|
+171,278
|
+3%
|
|
|
7
|
Great Point Partners
Greenwich,
Connecticut
|
$48.5M
|
-$14.3M
|
-1,666,494
|
-22%
|
|
|
8
|
State Street
Boston,
Massachusetts
|
$28.6M
|
+$6.11M
|
+713,082
|
+25%
|
|
|
9
|
Fidelity Investments
Boston,
Massachusetts
|
$28.2M
|
+$4.08M
|
+475,989
|
+16%
|
|
|
10
|
VHCP Management II
New York
|
$26.4M
|
–
|
–
|
–
|
|
|
11
|
Jennison Associates
New York
|
$25.2M
|
-$5.98M
|
-697,989
|
-18%
|
|
|
12
|
VHCP Management III
New York
|
$24.9M
|
–
|
–
|
–
|
|
|
13
|
Citadel Advisors
Miami,
Florida
|
$18M
|
+$12.7M
|
+1,488,671
|
+207%
|
|
|
14
|
Millennium Management
New York
|
$12.7M
|
+$6.41M
|
+748,758
|
+93%
|
|
|
15
|
Northern Trust
Chicago,
Illinois
|
$11.1M
|
+$88.3K
|
+10,318
|
+0.8%
|
|
|
16
|
|
$10.9M
|
-$1.38M
|
-160,787
|
-11%
|
|
|
17
|
Geode Capital Management
Boston,
Massachusetts
|
$10.8M
|
+$828K
|
+96,746
|
+8%
|
|
|
18
|
Bank of New York Mellon
New York
|
$7.35M
|
+$3.08M
|
+359,634
|
+66%
|
|
|
19
|
|
$7.19M
|
-$1.04M
|
-121,815
|
-12%
|
|
|
20
|
Charles Schwab
San Francisco,
California
|
$6.34M
|
+$1.55M
|
+181,543
|
+30%
|
|
|
21
|
Federated Hermes
Pittsburgh,
Pennsylvania
|
$6.34M
|
+$2.94M
|
+343,269
|
+79%
|
|
|
22
|
Rock Springs Capital Management
Baltimore,
Maryland
|
$5.7M
|
–
|
–
|
–
|
|
|
23
|
UBS Group
Zurich,
Switzerland
|
$4.16M
|
+$3.3M
|
+385,569
|
+307%
|
|
|
24
|
TIAA CREF Investment Management
New York
|
$4.16M
|
+$16.3K
|
+1,900
|
+0.4%
|
|
|
25
|
Ghost Tree Capital
New York
|
$4.07M
|
–
|
–
|
–
|
|
