|
1
|
Baker Bros. Advisors
New York
|
$48.4M
|
-$16.2M
|
-4,046,590
|
-27%
|
|
|
2
|
VHCP Management II
New York
|
$25.2M
|
–
|
–
|
–
|
|
|
3
|
Deerfield Management
New York
|
$19.4M
|
+$17.6M
|
+4,401,846
|
New
|
|
|
4
|
|
$18.5M
|
+$7.86M
|
+1,967,513
|
+88%
|
|
|
5
|
|
$16.2M
|
+$924K
|
+231,215
|
+7%
|
|
|
6
|
Vanguard Group
Malvern,
Pennsylvania
|
$15.7M
|
+$120K
|
+29,956
|
+0.8%
|
|
|
7
|
BlackRock Fund Advisors
San Francisco,
California
|
$13.4M
|
+$708K
|
+177,357
|
+6%
|
|
|
8
|
RA Capital Management
Boston,
Massachusetts
|
$13.2M
|
–
|
–
|
–
|
|
|
9
|
BlackRock Institutional Trust
San Francisco,
California
|
$8.63M
|
+$410K
|
+102,535
|
+6%
|
|
|
10
|
Ghost Tree Capital
New York
|
$7.94M
|
+$399K
|
+100,000
|
+6%
|
|
|
11
|
Avoro Capital Advisors
New York
|
$6.08M
|
+$5.51M
|
+1,379,402
|
New
|
|
|
12
|
Jennison Associates
New York
|
$5.96M
|
-$19.9K
|
-4,972
|
-0.4%
|
|
|
13
|
State Street
Boston,
Massachusetts
|
$5.95M
|
+$35.8K
|
+8,960
|
+0.7%
|
|
|
14
|
|
$4.43M
|
–
|
–
|
–
|
|
|
15
|
|
$4.27M
|
+$3.86M
|
+967,292
|
New
|
|
|
16
|
|
$3.96M
|
-$996K
|
-249,338
|
-22%
|
|
|
17
|
Northern Trust
Chicago,
Illinois
|
$3.77M
|
-$31.7K
|
-7,934
|
-0.9%
|
|
|
18
|
Acuta Capital Partners
Redwood City,
California
|
$2.44M
|
+$2.21M
|
+554,448
|
New
|
|
|
19
|
Deutsche Bank
Frankfurt Am Main Ge,
Germany
|
$2.28M
|
+$1.07M
|
+267,872
|
+107%
|
|
|
20
|
Geode Capital Management
Boston,
Massachusetts
|
$2.2M
|
+$24.2K
|
+6,062
|
+1%
|
|
|
21
|
TIAA CREF Investment Management
New York
|
$1.7M
|
-$11.2K
|
-2,811
|
-0.7%
|
|
|
22
|
|
$1.6M
|
+$399K
|
+100,000
|
+38%
|
|
|
23
|
Bank of New York Mellon
New York
|
$1.41M
|
+$49.2K
|
+12,316
|
+4%
|
|
|
24
|
BlackRock Investment Management
Wilmington,
Delaware
|
$1.3M
|
+$67.9K
|
+17,000
|
+6%
|
|
|
25
|
Charles Schwab
San Francisco,
California
|
$1.14M
|
+$45.8K
|
+11,454
|
+5%
|
|
