|
1
|
Baker Bros. Advisors
New York
|
$65.1M
|
–
|
–
|
–
|
|
|
2
|
|
$34.8M
|
+$1.49M
|
+244,100
|
+4%
|
|
|
3
|
Vanguard Group
Malvern,
Pennsylvania
|
$33.4M
|
+$6.07M
|
+996,052
|
+20%
|
|
|
4
|
RA Capital Management
Boston,
Massachusetts
|
$28.7M
|
+$10.2M
|
+1,672,447
|
+48%
|
|
|
5
|
State Street
Boston,
Massachusetts
|
$21.7M
|
+$9.97M
|
+1,636,909
|
+72%
|
|
|
6
|
Deerfield Management
New York
|
$19.5M
|
+$2.52M
|
+413,966
|
+13%
|
|
|
7
|
Millennium Management
New York
|
$18.9M
|
+$3.45M
|
+567,215
|
+20%
|
|
|
8
|
|
$18.5M
|
-$756K
|
-124,162
|
-4%
|
|
|
9
|
Fidelity Investments
Boston,
Massachusetts
|
$17.4M
|
+$10.2M
|
+1,667,791
|
+114%
|
|
|
10
|
VHCP Management II
New York
|
$13.8M
|
-$21.9M
|
-3,595,975
|
-59%
|
|
|
11
|
|
$11.6M
|
-$6.49M
|
-1,065,621
|
-34%
|
|
|
12
|
Jennison Associates
New York
|
$11.6M
|
+$1.44M
|
+236,182
|
+13%
|
|
|
13
|
Avoro Capital Advisors
New York
|
$10.9M
|
+$2.14M
|
+350,524
|
+22%
|
|
|
14
|
Northern Trust
Chicago,
Illinois
|
$5.6M
|
+$597K
|
+98,077
|
+11%
|
|
|
15
|
|
$5.32M
|
+$767
|
+126
|
+0%
|
|
|
16
|
|
$5.14M
|
+$835K
|
+137,068
|
+17%
|
|
|
17
|
|
$4.73M
|
+$2.13M
|
+350,000
|
+70%
|
|
|
18
|
Ghost Tree Capital
New York
|
$3.75M
|
-$5.03M
|
-825,000
|
-55%
|
|
|
19
|
Geode Capital Management
Boston,
Massachusetts
|
$3.64M
|
-$722K
|
-118,531
|
-15%
|
|
|
20
|
DAFNA Capital Management
Los Angeles,
California
|
$3.29M
|
+$305K
|
+50,000
|
+9%
|
|
|
21
|
Deutsche Bank
Frankfurt Am Main Ge,
Germany
|
$2.89M
|
+$1.8M
|
+295,626
|
+132%
|
|
|
22
|
TIAA CREF Investment Management
New York
|
$2.61M
|
+$711K
|
+116,782
|
+33%
|
|
|
23
|
University of Notre Dame du Lac
South Bend,
Indiana
|
$2.35M
|
+$613K
|
+100,603
|
+31%
|
|
|
24
|
Renaissance Technologies
New York
|
$2.25M
|
+$1.13M
|
+185,300
|
+85%
|
|
|
25
|
Bank of New York Mellon
New York
|
$2.06M
|
+$50.4K
|
+8,272
|
+2%
|
|
