|
1
|
Baker Bros. Advisors
New York
|
$98.4M
|
+$5.24M
|
+752,840
|
+7%
|
|
|
2
|
VHCP Management II
New York
|
$51M
|
–
|
–
|
–
|
|
|
3
|
|
$50.5M
|
+$41.8M
|
+6,004,070
|
+58,823%
|
|
|
4
|
Vanguard Group
Malvern,
Pennsylvania
|
$42.1M
|
+$11.5M
|
+1,651,292
|
+49%
|
|
|
5
|
RA Capital Management
Boston,
Massachusetts
|
$29.3M
|
+$3.48M
|
+500,000
|
+17%
|
|
|
6
|
|
$29M
|
-$4.32M
|
-620,775
|
-15%
|
|
|
7
|
|
$26.5M
|
-$3.68M
|
-529,523
|
-14%
|
|
|
8
|
Deerfield Management
New York
|
$25.9M
|
-$1.06M
|
-152,498
|
-5%
|
|
|
9
|
Millennium Management
New York
|
$23.8M
|
+$18.4M
|
+2,651,655
|
+1,418%
|
|
|
10
|
State Street
Boston,
Massachusetts
|
$19.1M
|
+$1.25M
|
+179,216
|
+9%
|
|
|
11
|
Jennison Associates
New York
|
$15.5M
|
+$3.41M
|
+489,536
|
+36%
|
|
|
12
|
Avoro Capital Advisors
New York
|
$13.5M
|
-$198K
|
-28,501
|
-2%
|
|
|
13
|
Ghost Tree Capital
New York
|
$12.6M
|
+$2.43M
|
+350,000
|
+30%
|
|
|
14
|
Fidelity Investments
Boston,
Massachusetts
|
$12.2M
|
+$5M
|
+719,162
|
+97%
|
|
|
15
|
Bogle Investment Management
Newton Lower Falls,
Massachusetts
|
$9.06M
|
+$7.5M
|
+1,078,345
|
New
|
|
|
16
|
|
$8.03M
|
-$74.8K
|
-10,756
|
-1%
|
|
|
17
|
Acuta Capital Partners
Redwood City,
California
|
$7.73M
|
+$5.36M
|
+770,310
|
+514%
|
|
|
18
|
Northern Trust
Chicago,
Illinois
|
$7.63M
|
+$252K
|
+36,243
|
+4%
|
|
|
19
|
|
$6.62M
|
+$322K
|
+46,249
|
+6%
|
|
|
20
|
Geode Capital Management
Boston,
Massachusetts
|
$6.49M
|
+$1.78M
|
+255,975
|
+49%
|
|
|
21
|
DAFNA Capital Management
Los Angeles,
California
|
$4.54M
|
+$3.31M
|
+475,228
|
+721%
|
|
|
22
|
|
$4.2M
|
+$3.48M
|
+500,000
|
New
|
|
|
23
|
|
$3.98M
|
+$1.02M
|
+146,220
|
+45%
|
|
|
24
|
Two Sigma Investments
New York
|
$3.84M
|
+$2.9M
|
+417,339
|
+1,035%
|
|
|
25
|
Emory University
Atlanta,
Georgia
|
$3.15M
|
+$2.61M
|
+375,348
|
New
|
|
