|
1
|
Baker Bros. Advisors
New York
|
$122M
|
–
|
–
|
–
|
|
|
2
|
Janus Henderson Group
London,
|
$99.3M
|
+$407K
|
+52,394
|
+0.4%
|
|
|
3
|
RA Capital Management
Boston,
Massachusetts
|
$86M
|
+$11.1M
|
+1,425,657
|
+15%
|
|
|
4
|
|
$71.4M
|
+$619K
|
+79,571
|
+0.9%
|
|
|
5
|
Great Point Partners
Greenwich,
Connecticut
|
$61.5M
|
-$2.77M
|
-356,019
|
-4%
|
|
|
6
|
Deerfield Management
New York
|
$55.8M
|
–
|
–
|
–
|
|
|
7
|
Vanguard Group
Malvern,
Pennsylvania
|
$47.4M
|
+$575K
|
+74,000
|
+1%
|
|
|
8
|
Jennison Associates
New York
|
$30.7M
|
-$398K
|
-51,150
|
-1%
|
|
|
9
|
VHCP Management II
New York
|
$26.2M
|
–
|
–
|
–
|
|
|
10
|
VHCP Management III
New York
|
$24.7M
|
–
|
–
|
–
|
|
|
11
|
Fidelity Investments
Boston,
Massachusetts
|
$24.1M
|
-$5.92M
|
-761,794
|
-20%
|
|
|
12
|
State Street
Boston,
Massachusetts
|
$22.6M
|
-$4.66M
|
-598,741
|
-18%
|
|
|
13
|
|
$12.1M
|
-$1.62M
|
-208,837
|
-12%
|
|
|
14
|
Northern Trust
Chicago,
Illinois
|
$10.9M
|
-$25K
|
-3,217
|
-0.2%
|
|
|
15
|
Geode Capital Management
Boston,
Massachusetts
|
$9.91M
|
+$846K
|
+108,785
|
+10%
|
|
|
16
|
Eventide Asset Management
Boston,
Massachusetts
|
$8.45M
|
–
|
–
|
–
|
|
|
17
|
|
$8.11M
|
+$897K
|
+115,333
|
+13%
|
|
|
18
|
Millennium Management
New York
|
$6.52M
|
-$2.89M
|
-371,780
|
-32%
|
|
|
19
|
Citadel Advisors
Miami,
Florida
|
$5.81M
|
+$5.18M
|
+665,917
|
+1,227%
|
|
|
20
|
Rock Springs Capital Management
Baltimore,
Maryland
|
$5.65M
|
–
|
–
|
–
|
|
|
21
|
Charles Schwab
San Francisco,
California
|
$4.83M
|
-$141K
|
-18,081
|
-3%
|
|
|
22
|
Bank of New York Mellon
New York
|
$4.38M
|
+$950K
|
+122,201
|
+29%
|
|
|
23
|
TIAA CREF Investment Management
New York
|
$4.1M
|
+$26.5K
|
+3,402
|
+0.7%
|
|
|
24
|
Ghost Tree Capital
New York
|
$4.04M
|
–
|
–
|
–
|
|
|
25
|
DAFNA Capital Management
Los Angeles,
California
|
$3.75M
|
-$1.46M
|
-187,671
|
-29%
|
|
