|
1
|
Baker Bros. Advisors
New York
|
$42.6M
|
–
|
–
|
–
|
|
|
2
|
VHCP Management II
New York
|
$16.2M
|
+$3.2M
|
+1,031,707
|
+22%
|
|
|
3
|
Vanguard Group
Malvern,
Pennsylvania
|
$10M
|
+$879K
|
+283,202
|
+9%
|
|
|
4
|
|
$9.75M
|
-$1.93M
|
-621,414
|
-15%
|
|
|
5
|
RA Capital Management
Boston,
Massachusetts
|
$8.49M
|
–
|
–
|
–
|
|
|
6
|
BlackRock Fund Advisors
San Francisco,
California
|
$8.1M
|
+$154K
|
+49,452
|
+2%
|
|
|
7
|
|
$6.35M
|
+$817K
|
+263,134
|
+13%
|
|
|
8
|
BlackRock Institutional Trust
San Francisco,
California
|
$5.26M
|
-$44.1K
|
-14,210
|
-0.8%
|
|
|
9
|
Ghost Tree Capital
New York
|
$4.83M
|
+$5.28M
|
+1,700,000
|
New
|
|
|
10
|
Jennison Associates
New York
|
$3.85M
|
-$4.04K
|
-1,302
|
-0.1%
|
|
|
11
|
State Street
Boston,
Massachusetts
|
$3.8M
|
-$12.4K
|
-3,984
|
-0.3%
|
|
|
12
|
|
$3.25M
|
-$284K
|
-91,338
|
-7%
|
|
|
13
|
|
$2.85M
|
+$1.37M
|
+442,161
|
+79%
|
|
|
14
|
Northern Trust
Chicago,
Illinois
|
$2.45M
|
+$97.1K
|
+31,262
|
+4%
|
|
|
15
|
Geode Capital Management
Boston,
Massachusetts
|
$1.4M
|
-$26.5K
|
-8,543
|
-2%
|
|
|
16
|
Tang Capital Management
San Diego,
California
|
$1.22M
|
–
|
–
|
–
|
|
|
17
|
TIAA CREF Investment Management
New York
|
$1.1M
|
+$190K
|
+61,277
|
+19%
|
|
|
18
|
Bank of New York Mellon
New York
|
$870K
|
-$1.71K
|
-552
|
-0.2%
|
|
|
19
|
Globeflex Capital
San Diego,
California
|
$829K
|
-$379K
|
-122,000
|
-29%
|
|
|
20
|
BlackRock Investment Management
Wilmington,
Delaware
|
$790K
|
+$51.2K
|
+16,483
|
+6%
|
|
|
21
|
|
$747K
|
–
|
–
|
–
|
|
|
22
|
Wellington Management Group
Boston,
Massachusetts
|
$727K
|
-$3.85M
|
-1,240,739
|
-83%
|
|
|
23
|
Deutsche Bank
Frankfurt Am Main Ge,
Germany
|
$705K
|
-$125K
|
-40,132
|
-14%
|
|
|
24
|
Charles Schwab
San Francisco,
California
|
$698K
|
+$11K
|
+3,528
|
+1%
|
|
|
25
|
Spark Investment Management
New York
|
$516K
|
-$1.08M
|
-348,300
|
-66%
|
|
