We are live on
!
Find out more
SCM
Sio Capital Management Portfolio holdings
AUM
$697M
1-Year Est. Return
79.73%
This Fund
S&P 500
This Quarter
Est. Return
+1.1%
1 Year Est. Return
+79.73%
3 Year Est. Return
+576.62%
5 Year Est. Return
+422.76%
10 Year Est. Return
+2,506.65%
AUM
$262M
AUM Growth
-$74M
(-22%)
Cap. Flow
-$64.8M
Cap. Flow
% of AUM
-24.76%
Top 10 Holdings %
Top 10 Hldgs %
58.8%
Holding
64
New
10
Increased
31
Reduced
6
Closed
12
Top Buys
| Rank | Stock | Value |
|---|---|---|
| 1 |
Centene
CNC
|
+$15.4M |
| 2 |
Disc Medicine
IRON
|
+$9.92M |
| 3 |
Sanofi
SNY
|
+$9.58M |
| 4 |
Edgewise Therapeutics
EWTX
|
+$7.78M |
| 5 |
Maximus
MMS
|
+$5.6M |
Top Sells
| Rank | Stock | Value |
|---|---|---|
| 1 |
Icon
ICLR
|
+$35.6M |
| 2 |
Zimmer Biomet
ZBH
|
+$21.2M |
| 3 |
Labcorp
LH
|
+$19.5M |
| 4 |
Teleflex
TFX
|
+$14.9M |
| 5 |
Embecta
EMBC
|
+$12.1M |
Sector Composition
| Rank | Sector | Weight |
|---|---|---|
| 1 | Healthcare | 80.46% |
| 2 | Industrials | 14.69% |
| Name | Market Value | Portfolio Weight | Shares or Principal |
Change in Stake | Capital Flow | |
|---|---|---|---|---|---|---|
|
1
Maximus
MMS
$3.23B
| $38.5M | 14.69% |
548,086
+79,734
| +17% | +$5.6M |
|
|
2
Disc Medicine
IRON
$2.87B
| $15.1M | 5.76% |
284,787
+211,276
| +287% | +$9.92M |
|
3
Globus Medical
GMED
$10.7B
| $14.5M | 5.54% |
245,570
+38,570
| +19% | +$2.49M |
|
|
4
Centene
CNC
$31.8B
| $14.2M | 5.44% |
+262,500
| New | +$15.4M |
|
5
Merck
MRK
$324B
| $13.8M | 5.26% |
173,951
-96,645
| -36% | -$7.68M |
|
|
DRUG
6
Bright Minds Biosciences
DRUG
$715M
| $13.4M | 5.11% |
512,338
+4,776
| +0.9% | +$143K |
|
7
Neurocrine Biosciences
NBIX
$17.8B
| $12.7M | 4.84% |
100,725
-86,848
| -46% | -$9.96M |
|
8
BioMarin Pharmaceuticals
BMRN
$11.8B
| $12.4M | 4.73% |
225,114
+83,980
| +60% | +$4.95M |
|
9
Annexon
ANNX
$875M
| $9.83M | 3.75% |
4,095,764
+697,978
| +21% | +$1.4M |
|
10
PUT
Idexx Laboratories
IDXX
$44B
| $9.65M | 3.69% |
+18,000
| New | +$8.61M |
|
|
11
Sanofi
SNY
$106B
| $9.06M | 3.46% |
+187,500
| New | +$9.58M |
|
12
Tyra Biosciences
TYRA
$1.89B
| $7.75M | 2.96% |
810,274
+393,657
| +94% | +$3.74M |
|
13
ANI Pharmaceuticals
ANIP
$1.78B
| $7.37M | 2.81% |
112,923
+25,625
| +29% | +$1.67M |
|
|
14
Edgewise Therapeutics
EWTX
$4.49B
| $7.08M | 2.7% |
+539,730
| New | +$7.78M |
|
|
AVR
15
Anteris Technologies
AVR
$800M
| $6.97M | 2.66% |
1,839,022
-530,938
| -22% | -$2.16M |
|
|
SEPN
16
Septerna Inc
SEPN
$1.51B
| $6.18M | 2.36% |
584,435
-204,235
| -26% | -$1.68M |
|
17
Artivion
AORT
$1.26B
| $4.94M | 1.89% |
158,736
+37,558
| +31% | +$1.02M |
|
18
Dianthus Therapeutics
DNTH
$5.76B
| $4.4M | 1.68% |
236,070
+119,073
| +102% | +$2.23M |
|
19
ProQR Therapeutics
PRQR
$247M
| $4.23M | 1.62% |
2,075,139
+20,546
| +1% | +$33.4K |
|
20
PMV Pharmaceuticals
PMVP
$62.4M
| $3.96M | 1.51% |
3,735,396
| – | – |
|
21
Avanos Medical
AVNS
$1.17B
| $3.54M | 1.35% |
288,849
+2,860
| +1% | +$36K |
|
|
MRUS
22
DELISTED
Merus
MRUS
| $3.3M | 1.26% |
+62,719
| New | +$2.95M |
|
23
Aquestive Therapeutics
AQST
$469M
| $3.14M | 1.2% |
947,489
+555,860
| +142% | +$1.59M |
|
24
PUT
INmune Bio
INMB
$45.7M
| $3M | 1.15% |
+1,299,300
| New | +$9.53M |
|
|
VTYX
25
DELISTED
Ventyx Biosciences
VTYX
| $2.8M | 1.07% |
1,307,964
-1,274,691
| -49% | -$2.06M |
|
Similar funds
GUB
KLI
CA
JA
WIC
AAM
TCM
CA
Sio Capital Management's Q2 2025 Portfolio in Review
As of Q2 2025, Sio Capital Management held 64 positions worth $262M, down 22% from $336M the previous quarter. Its ten largest holdings account for 59% of the portfolio.
Sio Capital Management withdrew a net $64.8M in Q2 2025, closing 12 positions and reducing 6 holdings. Its most notable exit was Icon, an estimated $35.6M position sold in full.
By sector, the portfolio is most concentrated in Healthcare at 80% of assets, down from 89% a quarter earlier, followed by Industrials.
Against the trend, Sio Capital Management opened a new position in Centene worth $14.2M.
- Sio Capital Management's largest Q2 2025 buy was Centene: 262,500 shares worth $14.2M.
- Sio Capital Management added most to Disc Medicine in Q2 2025, an estimated $9.92M increase.
- Sio Capital Management's biggest Q2 2025 reduction was Embecta, cutting an estimated $12.1M.
- Sio Capital Management fully exited Icon in Q2 2025, selling an estimated $35.6M.
- Sio Capital Management's ten largest holdings make up 59% of its $262M portfolio in Q2 2025.
- Sio Capital Management opened 10 new positions and closed 12 in Q2 2025.
- Sio Capital Management's portfolio value fell 22% quarter-over-quarter to $262M.
Based on Sio Capital Management's 13F filing for Q2 2025, filed 13 Aug 2025.