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Sio Capital Management Portfolio holdings

AUM $604M
1-Year Est. Return 96.57%
This Fund
S&P 500
This Quarter Est. Return
+130.68%
1 Year Est. Return
+96.57%
3 Year Est. Return
+564.25%
5 Year Est. Return
+486.18%
10 Year Est. Return
+2,856.71%
AUM
$355M
AUM Growth
+$103M
Cap. Flow
+$181M
Cap. Flow %
51.07%
Top 10 Hldgs %
59.98%
Holding
61
New
22
Increased
9
Reduced
5
Closed
10

Top Buys

Rank Stock Value
1
ICLR icon
Icon
ICLR
+$45.7M
2
CI icon
Cigna
CI
+$22.8M
3
QTTB icon
Q32 Bio
QTTB
+$22M
4
SNY icon
Sanofi
SNY
+$19.7M
5
MMS icon
Maximus
MMS
+$18.5M

Top Sells

Rank Stock Value
1
TEVA icon
Teva Pharmaceuticals
TEVA
+$24.3M
2
LH icon
Labcorp
LH
+$13.8M
3
KVUE icon
Kenvue
KVUE
+$11M
4
BDSX icon
Biodesix
BDSX
+$7.72M
5
RLAY icon
Relay Therapeutics
RLAY
+$6.7M

Sector Composition

Rank Sector Weight
1 Healthcare 91.96%
2 Industrials 8.01%
3 Miscellaneous 0.03%
4 Consumer Staples 0%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
ICLR icon
1
Icon
ICLR
$13.1B
$41M 11.54%
+195,500
New +$45.7M
MMS icon
2
Maximus
MMS
$3.13B
$28.5M 8.01%
381,423
+226,281
+146% +$18.5M
CI icon
3
Cigna
CI
$73.7B
$27.1M 7.61%
98,003
+71,500
+270% +$22.8M
LH icon
4
Labcorp
LH
$27.2B
$26M 7.31%
113,293
-60,000
-35% -$13.8M
SNY icon
5
Sanofi
SNY
$107B
$18.7M 5.25%
+387,000
New +$19.7M
ZBH icon
6
Zimmer Biomet
ZBH
$19.2B
$18.5M 5.2%
174,811
+47,300
+37% +$5.08M
DRUG
7
Bright Minds Biosciences
DRUG
$714M
$16.3M 4.58%
+451,793
New +$15.9M
AVR
8
Anteris Technologies
AVR
$852M
$13.2M 3.72%
+2,370,000
New +$13.3M
ANNX icon
9
Annexon
ANNX
$942M
$12.1M 3.42%
2,367,007
+933,852
+65% +$5.75M
TFX icon
10
Teleflex
TFX
$5.92B
$11.9M 3.34%
66,772
+27,500
+70% +$5.65M
VTRS icon
11
Viatris
VTRS
$18.8B
$9.09M 2.56%
+730,000
New +$8.97M
OGN icon
12
Organon & Co
OGN
$3.61B
$9.05M 2.55%
+606,410
New +$9.88M
VTYX
13
DELISTED
Ventyx Biosciences
VTYX
$8.86M 2.49%
4,046,797
+2,074,849
+105% +$4.7M
ANIP icon
14
ANI Pharmaceuticals
ANIP
$1.67B
$8.85M 2.49%
+160,051
New +$9.19M
EMBC icon
15
Embecta
EMBC
$286M
$8.79M 2.47%
+425,574
New +$6.97M
VIR icon
16
Vir Biotechnology
VIR
$1.83B
$7.74M 2.18%
+1,054,651
New +$8.32M
VXRT
17
DELISTED
Vaxart
VXRT
$7.62M 2.15%
11,515,315
-2,092,929
-15% -$1.45M
TARA icon
18
Protara Therapeutics
TARA
$226M
$7.59M 2.14%
+1,437,500
New +$4.64M
CRGX
19
DELISTED
CARGO Therapeutics
CRGX
$6.82M 1.92%
473,292
+299,432
+172% +$5.43M
NMRA icon
20
Neumora Therapeutics
NMRA
$261M
$6.74M 1.9%
+636,300
New +$7.63M
SEPN
21
Septerna Inc
SEPN
$1.82B
$6.22M 1.75%
+271,687
New +$6.42M
PRQR icon
22
ProQR Therapeutics
PRQR
$323M
$5.44M 1.53%
+2,054,593
New +$6.52M
PMVP icon
23
PMV Pharmaceuticals
PMVP
$65.2M
$5.39M 1.52%
3,572,167
+357,928
+11% +$567K
IRON icon
24
Disc Medicine
IRON
$3.07B
$4.66M 1.31%
73,511
-114,430
-61% -$6.62M
ATXS
25
DELISTED
Astria Therapeutics
ATXS
$4.51M 1.27%
504,887
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1
2 3

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V
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MAM
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RCM
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AMG
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VCP
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EHI
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Sio Capital Management's Q4 2024 Portfolio in Review

As of Q4 2024, Sio Capital Management held 61 positions worth $355M, up 41% from $252M the previous quarter. Its ten largest holdings account for 60% of the portfolio.

Sio Capital Management deployed $181M of net new capital in Q4 2024, opening 22 new positions and adding to 9 existing holdings. Its largest new stake was Icon: 195,500 shares worth $41M.

By sector, the portfolio is most concentrated in Healthcare at 92% of assets, up from 78% a quarter earlier, followed by Industrials and Miscellaneous.

On the sell side, the largest reduction was Labcorp, an estimated $13.8M trimmed.

  • Sio Capital Management's largest Q4 2024 buy was Icon: 195,500 shares worth $41M.
  • Sio Capital Management added most to Cigna in Q4 2024, an estimated $22.8M increase.
  • Sio Capital Management's biggest Q4 2024 reduction was Labcorp, cutting an estimated $13.8M.
  • Sio Capital Management fully exited Teva Pharmaceuticals in Q4 2024, selling an estimated $24.3M.
  • Sio Capital Management's ten largest holdings make up 60% of its $355M portfolio in Q4 2024.
  • Sio Capital Management opened 22 new positions and closed 10 in Q4 2024.
  • Sio Capital Management's portfolio value rose 41% quarter-over-quarter to $355M.

Based on Sio Capital Management's 13F filing for Q4 2024, filed 14 Feb 2025.