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Sio Capital Management Portfolio holdings

AUM $604M Turnover 53.26%
1-Year Est. Return 96.57%
This Fund
S&P 500
This Quarter Est. Return
+54.77%
1 Year Est. Return
+96.57%
3 Year Est. Return
+564.25%
5 Year Est. Return
+486.18%
10 Year Est. Return
+2,856.71%
AUM
$439M
AUM Growth
+$116M
Cap. Flow
-$1.56M
Cap. Flow %
-0.36%
Top 10 Hldgs %
76.24%
Holding
61
New
9
Increased
9
Reduced
7
Closed
18
Avg Time Held Equity + Options
1 year
Top 10 Avg Time Held Equity + Options
0.6 years
Top 20 Avg Time Held Equity + Options
0.5 years
Avg Time Held Equity only
1.1 years
Top 10 Avg Time Held Equity only
0.7 years
Top 20 Avg Time Held Equity only
0.5 years

Top Buys

Rank Stock Value
1
MRTX
Mirati Therapeutics, Inc. Common Stock
MRTX
+$81.6M
2
CI icon
Cigna
CI
+$17M
3
GRCL
Gracell Biotechnologies Inc. American Depositary Shares
GRCL
+$13.3M
4
IMGN icon
Immunogen Inc
IMGN
+$8.2M
5
PTGX icon
Protagonist Therapeutics
PTGX
+$3.71M

Top Sells

Rank Stock Value
1
GEHC icon
GE HealthCare
GEHC
+$16.5M
2
BCYC icon
Bicycle Therapeutics
BCYC
+$16M
3
PFE icon
Pfizer
PFE
+$14.9M
4
OGN icon
Organon & Co
OGN
+$13.3M
5
REGN icon
Regeneron Pharmaceuticals
REGN
+$12.6M

Sector Composition

Rank Sector Weight
1 Healthcare 88.39%
2 Miscellaneous 11.61%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow Held Since
MRTX
1
DELISTED
Mirati Therapeutics, Inc. Common Stock
MRTX
$85.3M 19.42%
+1,451,925
New +$81.6M
2023 Q4
0 quarters
GRCL
2
DELISTED
Gracell Biotechnologies Inc. American Depositary Shares
GRCL
$50.2M 11.43%
5,001,580
+2,920,364
+140% +$13.3M
2023 Q3
1 quarter
LH icon
3
Labcorp
LH
$26.1B
$37.5M 8.55%
165,123
-3,686
-2% -$774K
2023 Q2
2 quarters
CI icon
4
Cigna
CI
$78.7B
$34.9M 7.95%
116,553
+58,327
+100% +$17M
2020 Q3
13 quarters
GMED icon
5
Globus Medical
GMED
$10.5B
$28.4M 6.46%
532,089
+15,108
+3% +$736K
2023 Q1
3 quarters
INSM icon
6
PUT
Insmed
INSM
$21.7B
$26.7M 6.08%
+861,700
New +$22.3M
2023 Q4
0 quarters
GSK icon
7
GSK
GSK
$98.4B
$21.2M 4.82%
571,391
+62,391
+12% +$2.24M
2023 Q2
2 quarters
IMGN icon
8
DELISTED
Immunogen Inc
IMGN
$19.1M 4.35%
644,366
+411,615
+177% +$8.2M
2023 Q2
2 quarters
UTHR icon
9
United Therapeutics
UTHR
$23.6B
$17.6M 4.01%
80,050
-1,556
-2% -$359K
2018 Q4
20 quarters
EMBC icon
10
Embecta
EMBC
$368M
$13.9M 3.17%
736,008
+167,714
+30% +$2.75M
2023 Q3
1 quarter
SRPT icon
11
PUT
Sarepta Therapeutics
SRPT
$1.87B
$13.6M 3.1%
+141,300
New +$13.6M
2023 Q4
0 quarters
PTGX icon
12
Protagonist Therapeutics
PTGX
$8.88B
$10.5M 2.4%
460,044
+211,917
+85% +$3.71M
2023 Q3
1 quarter
TFX icon
13
Teleflex
TFX
$5.39B
$9.11M 2.07%
36,527
-27,964
-43% -$5.98M
2023 Q3
1 quarter
ZBH icon
14
Zimmer Biomet
ZBH
$18B
$8.8M 2%
72,300
-1,100
-1% -$123K
2023 Q3
1 quarter
NEOG icon
15
PUT
Neogen
NEOG
$2.64B
$8.59M 1.96%
+427,000
New +$7.23M
2023 Q4
0 quarters
HCSG icon
16
Healthcare Services Group
HCSG
$1.47B
$8.4M 1.91%
810,307
– –
2023 Q3
1 quarter
SPRY icon
17
ARS Pharmaceuticals
SPRY
$405M
$6.06M 1.38%
1,105,911
– –
2023 Q2
2 quarters
BBIO icon
18
BridgeBio Pharma
BBIO
$13.1B
$5.32M 1.21%
131,753
-91,194
-41% -$2.74M
2023 Q3
1 quarter
OCUL icon
19
Ocular Therapeutix
OCUL
$1.6B
$4.33M 0.99%
+971,446
New +$2.87M
2023 Q4
0 quarters
MACK icon
20
DELISTED
Merrimack Pharmaceuticals, Inc.
MACK
$3.87M 0.88%
288,466
– –
2022 Q4
4 quarters
HARP
21
DELISTED
Harpoon Therapeutics, Inc. Common Stock
HARP
$3.39M 0.77%
297,936
+129,919
+77% +$1.02M
2023 Q3
1 quarter
XFOR icon
22
X4 Pharmaceuticals
XFOR
$254M
$3.01M 0.69%
119,614
+32,981
+38% +$802K
2023 Q2
2 quarters
FUSN icon
23
DELISTED
Fusion Pharmaceuticals Inc. Common Shares
FUSN
$2.36M 0.54%
246,036
– –
2020 Q4
12 quarters
CMPS icon
24
Compass Pathways
CMPS
$1.56B
$2.2M 0.5%
+251,532
New +$1.63M
2023 Q4
0 quarters
ARQT icon
25
Arcutis Biotherapeutics
ARQT
$3.6B
$2.05M 0.47%
635,969
– –
2023 Q2
2 quarters
1
2 3

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MAM
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RCM
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AMG
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Sio Capital Management's Q4 2023 Portfolio in Review

As of Q4 2023, Sio Capital Management held 61 positions worth $439M, up 36% from $323M the previous quarter. Its ten largest holdings account for 76% of the portfolio.

Sio Capital Management's Q4 2023 filing shows 9 new, 9 increased, 7 reduced and 18 closed positions. Its largest new stake was Mirati Therapeutics, Inc. Common Stock: 1,451,925 shares worth $85.3M. The largest sale was GE HealthCare, an estimated $16.5M.

By sector, the portfolio is most concentrated in Healthcare at 88% of assets, down from 100% a quarter earlier, followed by Miscellaneous.

  • Sio Capital Management's largest Q4 2023 buy was Mirati Therapeutics, Inc. Common Stock: 1,451,925 shares worth $85.3M.
  • Sio Capital Management added most to Cigna in Q4 2023, an estimated $17M increase.
  • Sio Capital Management's biggest Q4 2023 reduction was Teleflex, cutting an estimated $5.98M.
  • Sio Capital Management fully exited GE HealthCare in Q4 2023, selling an estimated $16.5M.
  • Sio Capital Management's ten largest holdings make up 76% of its $439M portfolio in Q4 2023.
  • Sio Capital Management opened 9 new positions and closed 18 in Q4 2023.
  • Sio Capital Management's portfolio value rose 36% quarter-over-quarter to $439M.

Based on Sio Capital Management's 13F filing for Q4 2023, filed 13 Feb 2024.