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Sio Capital Management Portfolio holdings

AUM $604M
1-Year Est. Return 96.57%
This Fund
S&P 500
This Quarter Est. Return
+54.77%
1 Year Est. Return
+96.57%
3 Year Est. Return
+564.25%
5 Year Est. Return
+486.18%
10 Year Est. Return
+2,856.71%
AUM
$439M
AUM Growth
+$116M
Cap. Flow
-$1.56M
Cap. Flow %
-0.36%
Top 10 Hldgs %
76.24%
Holding
61
New
9
Increased
9
Reduced
7
Closed
18

Top Buys

Rank Stock Value
1
MRTX
Mirati Therapeutics, Inc. Common Stock
MRTX
+$81.6M
2
CI icon
Cigna
CI
+$17M
3
GRCL
Gracell Biotechnologies Inc. American Depositary Shares
GRCL
+$13.3M
4
IMGN
Immunogen Inc
IMGN
+$8.2M
5
PTGX icon
Protagonist Therapeutics
PTGX
+$3.71M

Top Sells

Rank Stock Value
1
GEHC icon
GE HealthCare
GEHC
+$16.5M
2
BCYC
Bicycle Therapeutics
BCYC
+$16M
3
PFE icon
Pfizer
PFE
+$14.9M
4
OGN icon
Organon & Co
OGN
+$13.3M
5
REGN icon
Regeneron Pharmaceuticals
REGN
+$12.6M

Sector Composition

Rank Sector Weight
1 Healthcare 88.39%
2 Miscellaneous 11.61%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
MRTX
1
DELISTED
Mirati Therapeutics, Inc. Common Stock
MRTX
$85.3M 19.42%
+1,451,925
New +$81.6M
GRCL
2
DELISTED
Gracell Biotechnologies Inc. American Depositary Shares
GRCL
$50.2M 11.43%
5,001,580
+2,920,364
+140% +$13.3M
LH icon
3
Labcorp
LH
$27.2B
$37.5M 8.55%
165,123
-3,686
-2% -$774K
CI icon
4
Cigna
CI
$73.7B
$34.9M 7.95%
116,553
+58,327
+100% +$17M
GMED icon
5
Globus Medical
GMED
$11.1B
$28.4M 6.46%
532,089
+15,108
+3% +$736K
INSM icon
6
PUT
Insmed
INSM
$25.9B
$26.7M 6.08%
+861,700
New +$22.3M
GSK icon
7
GSK
GSK
$102B
$21.2M 4.82%
571,391
+62,391
+12% +$2.24M
IMGN
8
DELISTED
Immunogen Inc
IMGN
$19.1M 4.35%
644,366
+411,615
+177% +$8.2M
UTHR icon
9
United Therapeutics
UTHR
$22.1B
$17.6M 4.01%
80,050
-1,556
-2% -$359K
EMBC icon
10
Embecta
EMBC
$286M
$13.9M 3.17%
736,008
+167,714
+30% +$2.75M
SRPT icon
11
PUT
Sarepta Therapeutics
SRPT
$2.2B
$13.6M 3.1%
+141,300
New +$13.6M
PTGX icon
12
Protagonist Therapeutics
PTGX
$9.34B
$10.5M 2.4%
460,044
+211,917
+85% +$3.71M
TFX icon
13
Teleflex
TFX
$5.92B
$9.11M 2.07%
36,527
-27,964
-43% -$5.98M
ZBH icon
14
Zimmer Biomet
ZBH
$19.2B
$8.8M 2%
72,300
-1,100
-1% -$123K
NEOG icon
15
PUT
Neogen
NEOG
$2.54B
$8.59M 1.96%
+427,000
New +$7.23M
HCSG icon
16
Healthcare Services Group
HCSG
$1.54B
$8.4M 1.91%
810,307
– –
SPRY icon
17
ARS Pharmaceuticals
SPRY
$586M
$6.06M 1.38%
1,105,911
– –
BBIO icon
18
BridgeBio Pharma
BBIO
$15B
$5.32M 1.21%
131,753
-91,194
-41% -$2.74M
OCUL icon
19
Ocular Therapeutix
OCUL
$2.28B
$4.33M 0.99%
+971,446
New +$2.87M
MACK
20
DELISTED
Merrimack Pharmaceuticals, Inc.
MACK
$3.87M 0.88%
288,466
– –
HARP
21
DELISTED
Harpoon Therapeutics, Inc. Common Stock
HARP
$3.39M 0.77%
297,936
+129,919
+77% +$1.02M
XFOR icon
22
X4 Pharmaceuticals
XFOR
$401M
$3.01M 0.69%
119,614
+32,981
+38% +$802K
FUSN
23
DELISTED
Fusion Pharmaceuticals Inc. Common Shares
FUSN
$2.36M 0.54%
246,036
– –
CMPS
24
Compass Pathways
CMPS
$1.9B
$2.2M 0.5%
+251,532
New +$1.63M
ARQT icon
25
Arcutis Biotherapeutics
ARQT
$2.99B
$2.05M 0.47%
635,969
– –
1
2 3

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EFL
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V
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MAM
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RCM
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AMG
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VV
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VCP
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EHI
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Sio Capital Management's Q4 2023 Portfolio in Review

As of Q4 2023, Sio Capital Management held 61 positions worth $439M, up 36% from $323M the previous quarter. Its ten largest holdings account for 76% of the portfolio.

Sio Capital Management's Q4 2023 filing shows 9 new, 9 increased, 7 reduced and 18 closed positions. Its largest new stake was Mirati Therapeutics, Inc. Common Stock: 1,451,925 shares worth $85.3M. The largest sale was GE HealthCare, an estimated $16.5M.

By sector, the portfolio is most concentrated in Healthcare at 88% of assets, down from 100% a quarter earlier, followed by Miscellaneous.

  • Sio Capital Management's largest Q4 2023 buy was Mirati Therapeutics, Inc. Common Stock: 1,451,925 shares worth $85.3M.
  • Sio Capital Management added most to Cigna in Q4 2023, an estimated $17M increase.
  • Sio Capital Management's biggest Q4 2023 reduction was Teleflex, cutting an estimated $5.98M.
  • Sio Capital Management fully exited GE HealthCare in Q4 2023, selling an estimated $16.5M.
  • Sio Capital Management's ten largest holdings make up 76% of its $439M portfolio in Q4 2023.
  • Sio Capital Management opened 9 new positions and closed 18 in Q4 2023.
  • Sio Capital Management's portfolio value rose 36% quarter-over-quarter to $439M.

Based on Sio Capital Management's 13F filing for Q4 2023, filed 13 Feb 2024.