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Sio Capital Management Portfolio holdings

AUM $604M
1-Year Est. Return 96.57%
This Fund
S&P 500
This Quarter Est. Return
-15.5%
1 Year Est. Return
+96.57%
3 Year Est. Return
+564.25%
5 Year Est. Return
+486.18%
10 Year Est. Return
+2,856.71%
AUM
$336M
AUM Growth
-$19.6M
Cap. Flow
+$49.3M
Cap. Flow %
14.69%
Top 10 Hldgs %
64.26%
Holding
65
New
14
Increased
15
Reduced
7
Closed
11

Top Buys

Rank Stock Value
1
MRK icon
Merck
MRK
+$25.3M
2
NBIX icon
Neurocrine Biosciences
NBIX
+$23.8M
3
GMED icon
Globus Medical
GMED
+$17.1M
4
EMBC icon
Embecta
EMBC
+$10.9M
5
BMRN icon
BioMarin Pharmaceuticals
BMRN
+$9.49M

Top Sells

Rank Stock Value
1
CI icon
Cigna
CI
+$27.1M
2
SNY icon
Sanofi
SNY
+$18.7M
3
VTRS icon
Viatris
VTRS
+$9.09M
4
OGN icon
Organon & Co
OGN
+$9.05M
5
LH icon
Labcorp
LH
+$7.14M

Sector Composition

Rank Sector Weight
1 Healthcare 88.81%
2 Industrials 9.51%
3 Miscellaneous 1.68%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
ICLR icon
1
Icon
ICLR
$13.1B
$35.6M 10.59%
203,311
+7,811
+4% +$1.51M
MMS icon
2
Maximus
MMS
$3.13B
$31.9M 9.51%
468,352
+86,929
+23% +$6.19M
MRK icon
3
Merck
MRK
$366B
$24.3M 7.23%
+270,596
New +$25.3M
ZBH icon
4
Zimmer Biomet
ZBH
$19.2B
$21.2M 6.33%
187,685
+12,874
+7% +$1.38M
NBIX icon
5
Neurocrine Biosciences
NBIX
$15.7B
$20.7M 6.18%
+187,573
New +$23.8M
LH icon
6
Labcorp
LH
$27.2B
$19.5M 5.81%
83,873
-29,420
-26% -$7.14M
DRUG
7
Bright Minds Biosciences
DRUG
$714M
$18.3M 5.45%
507,562
+55,769
+12% +$2.04M
GMED icon
8
Globus Medical
GMED
$11.1B
$15.2M 4.51%
+207,000
New +$17.1M
TFX icon
9
Teleflex
TFX
$5.92B
$14.9M 4.44%
107,780
+41,008
+61% +$6.64M
EMBC icon
10
Embecta
EMBC
$286M
$14.1M 4.21%
1,107,613
+682,039
+160% +$10.9M
BMRN icon
11
BioMarin Pharmaceuticals
BMRN
$12.5B
$9.98M 2.97%
+141,134
New +$9.49M
AVR
12
Anteris Technologies
AVR
$852M
$8.63M 2.57%
2,369,960
-40
-0% -$257
HAE icon
13
Haemonetics
HAE
$4.73B
$8.51M 2.54%
+133,966
New +$9.11M
ANNX icon
14
Annexon
ANNX
$942M
$6.56M 1.95%
3,397,786
+1,030,779
+44% +$3.43M
TARA icon
15
Protara Therapeutics
TARA
$226M
$6.45M 1.92%
1,514,300
+76,800
+5% +$343K
ANIP icon
16
ANI Pharmaceuticals
ANIP
$1.67B
$5.84M 1.74%
87,298
-72,753
-45% -$4.35M
SLNO
17
PUT
DELISTED
Soleno Therapeutics
SLNO
$5.59M 1.67%
+78,300
New +$3.81M
SEPN
18
Septerna Inc
SEPN
$1.82B
$4.57M 1.36%
788,670
+516,983
+190% +$5.9M
PRAX icon
19
Praxis Precision Medicines
PRAX
$9.63B
$4.26M 1.27%
+112,500
New +$7.03M
AVNS
20
DELISTED
Avanos Medical
AVNS
$4.1M 1.22%
+285,989
New +$4.47M
PMVP icon
21
PMV Pharmaceuticals
PMVP
$65.2M
$4.07M 1.21%
3,735,396
+163,229
+5% +$222K
TYRA icon
22
Tyra Biosciences
TYRA
$1.49B
$3.87M 1.15%
416,617
+175,747
+73% +$2.27M
IRON icon
23
Disc Medicine
IRON
$3.07B
$3.65M 1.09%
73,511
– –
ETNB
24
DELISTED
89bio
ETNB
$3.63M 1.08%
+500,000
New +$4.37M
AKRO
25
DELISTED
Akero Therapeutics
AKRO
$3.44M 1.02%
+85,000
New +$3.6M
1
2 3

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EFL
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V
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MAM
Morse Asset Management Darien, Connecticut $604M AUM 72.61% 1-Year Est. Return
RCM
Requisite Capital Management Dallas, Texas $605M AUM 17.2% 1-Year Est. Return
AMG
Advisors Management Group La Crosse, Wisconsin $604M AUM 64.38% 1-Year Est. Return
VV
Verbena Value Westport, Connecticut $605M AUM
VCP
Varenne Capital Partners Paris, France $603M AUM 46.34% 1-Year Est. Return
EHI
Eagle Health Investments Greenwich, Connecticut $603M AUM 111.06% 1-Year Est. Return

Sio Capital Management's Q1 2025 Portfolio in Review

As of Q1 2025, Sio Capital Management held 65 positions worth $336M, down 5.5% from $355M the previous quarter. Its ten largest holdings account for 64% of the portfolio.

Sio Capital Management deployed $49.3M of net new capital in Q1 2025, opening 14 new positions and adding to 15 existing holdings. Its largest new stake was Merck: 270,596 shares worth $24.3M.

By sector, the portfolio is most concentrated in Healthcare at 89% of assets, down from 92% a quarter earlier, followed by Industrials and Miscellaneous.

On the sell side, the largest reduction was Labcorp, an estimated $7.14M trimmed.

  • Sio Capital Management's largest Q1 2025 buy was Merck: 270,596 shares worth $24.3M.
  • Sio Capital Management added most to Embecta in Q1 2025, an estimated $10.9M increase.
  • Sio Capital Management's biggest Q1 2025 reduction was Labcorp, cutting an estimated $7.14M.
  • Sio Capital Management fully exited Cigna in Q1 2025, selling an estimated $27.1M.
  • Sio Capital Management's ten largest holdings make up 64% of its $336M portfolio in Q1 2025.
  • Sio Capital Management opened 14 new positions and closed 11 in Q1 2025.
  • Sio Capital Management's portfolio value fell 5.5% quarter-over-quarter to $336M.

Based on Sio Capital Management's 13F filing for Q1 2025, filed 15 May 2025.