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Sio Capital Management Portfolio holdings

AUM $604M
1-Year Est. Return 96.57%
This Fund
S&P 500
This Quarter Est. Return
+25.71%
1 Year Est. Return
+96.57%
3 Year Est. Return
+564.25%
5 Year Est. Return
+486.18%
10 Year Est. Return
+2,856.71%
AUM
$336M
AUM Growth
-$103M
Cap. Flow
-$131M
Cap. Flow %
-39%
Top 10 Hldgs %
58.57%
Holding
65
New
22
Increased
6
Reduced
11
Closed
14

Top Buys

Rank Stock Value
1
LH icon
Labcorp
LH
+$13.4M
2
MDGL icon
Madrigal Pharmaceuticals
MDGL
+$12M
3
MDT icon
Medtronic
MDT
+$8.96M
4
TYRA icon
Tyra Biosciences
TYRA
+$8.79M
5
OGN icon
Organon & Co
OGN
+$8.22M

Top Sells

Rank Stock Value
1
MRTX
Mirati Therapeutics, Inc. Common Stock
MRTX
+$85.3M
2
GRCL
Gracell Biotechnologies Inc. American Depositary Shares
GRCL
+$50.2M
3
IMGN
Immunogen Inc
IMGN
+$19.1M
4
UTHR icon
United Therapeutics
UTHR
+$17.6M
5
CI icon
Cigna
CI
+$13.3M

Sector Composition

Rank Sector Weight
1 Healthcare 85.46%
2 Miscellaneous 14.54%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
LH icon
1
Labcorp
LH
$27.2B
$49.4M 14.69%
225,902
+60,779
+37% +$13.4M
INSM icon
2
PUT
Insmed
INSM
$25.9B
$37M 11.01%
1,362,700
+501,000
+58% +$14M
CI icon
3
Cigna
CI
$73.7B
$27.6M 8.23%
76,086
-40,467
-35% -$13.3M
GMED icon
4
Globus Medical
GMED
$11.1B
$21.1M 6.28%
393,420
-138,669
-26% -$7.46M
MDGL icon
5
Madrigal Pharmaceuticals
MDGL
$12.3B
$13.6M 4.06%
+51,000
New +$12M
GSK icon
6
GSK
GSK
$102B
$11.3M 3.36%
263,445
-307,946
-54% -$12.7M
ZBH icon
7
Zimmer Biomet
ZBH
$19.2B
$9.79M 2.92%
74,179
+1,879
+3% +$235K
MDT icon
8
Medtronic
MDT
$117B
$9.15M 2.72%
+105,000
New +$8.96M
OGN icon
9
Organon & Co
OGN
$3.61B
$9.01M 2.68%
+479,023
New +$8.22M
TYRA icon
10
Tyra Biosciences
TYRA
$1.49B
$8.79M 2.62%
+535,741
New +$8.79M
IRWD icon
11
PUT
Ironwood Pharmaceuticals
IRWD
$682M
$8.46M 2.52%
970,800
+807,400
+494% +$9.8M
EMBC icon
12
Embecta
EMBC
$286M
$7.77M 2.31%
585,418
-150,590
-20% -$2.33M
TFX icon
13
Teleflex
TFX
$5.92B
$7.66M 2.28%
33,878
-2,649
-7% -$629K
ARQT icon
14
Arcutis Biotherapeutics
ARQT
$2.99B
$6.3M 1.88%
635,969
– –
BBIO icon
15
BridgeBio Pharma
BBIO
$15B
$6.28M 1.87%
203,174
+71,421
+54% +$2.43M
HUMA icon
16
Humacyte
HUMA
$181M
$6.22M 1.85%
+2,000,000
New +$6.73M
ANIP icon
17
ANI Pharmaceuticals
ANIP
$1.67B
$6.04M 1.8%
+87,354
New +$5.27M
ATXS
18
DELISTED
Astria Therapeutics
ATXS
$5.77M 1.72%
+410,267
New +$5.11M
SPRY icon
19
ARS Pharmaceuticals
SPRY
$586M
$5.48M 1.63%
536,163
-569,748
-52% -$4.25M
HCSG icon
20
Healthcare Services Group
HCSG
$1.54B
$5.26M 1.57%
421,317
-388,990
-48% -$4.31M
APGE icon
21
Apogee Therapeutics
APGE
$10.2B
$5.18M 1.54%
+78,000
New +$3.41M
FUSN
22
DELISTED
Fusion Pharmaceuticals Inc. Common Shares
FUSN
$5.18M 1.54%
243,035
-3,001
-1% -$35.9K
ERAS icon
23
Erasca
ERAS
$6.31B
$5M 1.49%
+2,427,184
New +$4.85M
XFOR icon
24
X4 Pharmaceuticals
XFOR
$401M
$4.99M 1.49%
119,614
– –
NUVB icon
25
Nuvation Bio
NUVB
$2.34B
$4.86M 1.45%
+1,336,231
New +$2.57M
1
2 3

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V
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MAM
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RCM
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AMG
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VV
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VCP
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EHI
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Sio Capital Management's Q1 2024 Portfolio in Review

As of Q1 2024, Sio Capital Management held 65 positions worth $336M, down 24% from $439M the previous quarter. Its ten largest holdings account for 59% of the portfolio.

Sio Capital Management withdrew a net $131M in Q1 2024, closing 14 positions and reducing 11 holdings. Its most notable exit was Mirati Therapeutics, Inc. Common Stock, an estimated $85.3M position sold in full.

By sector, the portfolio is most concentrated in Healthcare at 85% of assets, down from 88% a quarter earlier, followed by Miscellaneous.

Against the trend, Sio Capital Management opened a new position in Madrigal Pharmaceuticals worth $13.6M.

  • Sio Capital Management's largest Q1 2024 buy was Madrigal Pharmaceuticals: 51,000 shares worth $13.6M.
  • Sio Capital Management added most to Labcorp in Q1 2024, an estimated $13.4M increase.
  • Sio Capital Management's biggest Q1 2024 reduction was Cigna, cutting an estimated $13.3M.
  • Sio Capital Management fully exited Mirati Therapeutics, Inc. Common Stock in Q1 2024, selling an estimated $85.3M.
  • Sio Capital Management's ten largest holdings make up 59% of its $336M portfolio in Q1 2024.
  • Sio Capital Management opened 22 new positions and closed 14 in Q1 2024.
  • Sio Capital Management's portfolio value fell 24% quarter-over-quarter to $336M.

Based on Sio Capital Management's 13F filing for Q1 2024, filed 15 May 2024.