Sio Capital Management’s Tyra Biosciences TYRA Stock Holding History

Sio Capital Management’s Portfolio TYRA Stock Details TYRA Fund Activity

Bought

Maintained

Sold

Quarter	Market Value	Status	Shares	Change in Stake	Trade Value	Portfolio Weight	Portfolio Position
2026 Q1	$23.2M	Buy	605,439 +79,437	+15%	+$2.57M	3.33%	9
2025 Q4	$13.8M	Buy	526,002 +11,055	+2%	+$203K	2.18%	16
2025 Q3	$7.2M	Sell	514,947 -295,327	-36%	-$3.37M	1.82%	19
2025 Q2	$7.75M	Buy	810,274 +393,657	+94%	+$3.74M	2.96%	12
2025 Q1	$3.87M	Buy	416,617 +175,747	+73%	+$2.27M	1.15%	22
2024 Q4	$3.35M	Sell	240,870 -160,000	-40%	-$2.9M	0.94%	29
2024 Q3	$9.42M	Sell	400,870 -199,424	-33%	-$4.19M	3.74%	9
2024 Q2	$9.6M	Buy	600,294 +64,553	+12%	+$1.11M	2.6%	11
2024 Q1	$8.79M	Buy	+535,741	New	+$8.79M	2.62%	10
2023 Q1	–	Sell	-152,159	Closed	-$1.16M	–	56
2022 Q4	$1.16M	Hold	152,159	–	–	0.43%	31
2022 Q3	$1.34M	Hold	152,159	–	–	0.42%	31
2022 Q2	$1.09M	Buy	152,159 +41,126	+37%	+$327K	0.41%	41
2022 Q1	$1.19M	Buy	+111,033	New	+$1.32M	0.39%	45

Other funds holding TYRA

RCM

RA Capital Management Boston, Massachusetts $9.44B AUM 157.3% 1-Year Est. Return

Fidelity Investments Boston, Massachusetts $1.9T AUM 41.92% 1-Year Est. Return

Nextech Invest Zurich, Switzerland $1.42B AUM 304.47% 1-Year Est. Return

Janus Henderson Group London, United Kingdom $209B AUM 37.72% 1-Year Est. Return

APMC

Alta Partners Management Company Jackson, Wyoming $151M AUM 296.21% 1-Year Est. Return

FCM

Farallon Capital Management San Francisco, California $17.5B AUM 50.95% 1-Year Est. Return

TCM

TCG Crossover Management Palo Alto, California $3.5B AUM 1,165.83% 1-Year Est. Return

Commodore Capital New York $1.73B AUM 298.96% 1-Year Est. Return

BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return

PBA

Paradigm Biocapital Advisors New York $4.89B AUM 251.12% 1-Year Est. Return

Sio Capital Management's TYRA Position: Q1 2026 in Review

Sio Capital Management increased its Tyra Biosciences (TYRA) stake by 15% in Q1 2026, buying an estimated $2.57M and bringing the position to 605,439 shares worth $23.2M. The position accounts for 3.33% of the portfolio, ranked #9.

Sio Capital Management first reported a position in TYRA in Q1 2022 and has held it in 13 quarters since. 164 funds tracked by Wall St. Rank hold TYRA as of Q1 2026.

Sio Capital Management held 605,439 shares of Tyra Biosciences worth $23.2M as of Q1 2026.
Sio Capital Management bought 79,437 Tyra Biosciences shares in Q1 2026, an estimated $2.57M.
Tyra Biosciences made up 3.33% of Sio Capital Management's portfolio in Q1 2026, its #9 holding.
Sio Capital Management first reported a position in Tyra Biosciences in Q1 2022 and has held it in 13 quarters since.
164 funds tracked by Wall St. Rank held Tyra Biosciences as of Q1 2026.

Based on Sio Capital Management's 13F filing for Q1 2026, filed 14 May 2026.