Sio Capital Management’s Tyra Biosciences TYRA Stock Holding History

Sio Capital Management’s Portfolio TYRA Stock Details TYRA Fund Activity

Bought

Maintained

Sold

Quarter	Market Value	Status	Shares	Change in Stake	Trade Value	Portfolio Weight	Portfolio Position
2026 Q2	$22.2M	Buy	695,315 +89,876	+15%	+$2.97M	3.68%	7
2026 Q1	$23.2M	Buy	605,439 +79,437	+15%	+$2.57M	3.33%	9
2025 Q4	$13.8M	Buy	526,002 +11,055	+2%	+$203K	2.18%	16
2025 Q3	$7.2M	Sell	514,947 -295,327	-36%	-$3.37M	1.82%	19
2025 Q2	$7.75M	Buy	810,274 +393,657	+94%	+$3.74M	2.96%	12
2025 Q1	$3.87M	Buy	416,617 +175,747	+73%	+$2.27M	1.15%	22
2024 Q4	$3.35M	Sell	240,870 -160,000	-40%	-$2.9M	0.94%	29
2024 Q3	$9.42M	Sell	400,870 -199,424	-33%	-$4.19M	3.74%	9
2024 Q2	$9.6M	Buy	600,294 +64,553	+12%	+$1.11M	2.6%	11
2024 Q1	$8.79M	Buy	+535,741	New	+$8.79M	2.62%	10
2023 Q1	–	Sell	-152,159	Closed	-$1.16M	–	56
2022 Q4	$1.16M	Hold	152,159	–	–	0.43%	31
2022 Q3	$1.34M	Hold	152,159	–	–	0.42%	31
2022 Q2	$1.09M	Buy	152,159 +41,126	+37%	+$327K	0.41%	41
2022 Q1	$1.19M	Buy	+111,033	New	+$1.32M	0.39%	45

Other funds holding TYRA

RCM

RA Capital Management Boston, Massachusetts $11.5B AUM 168.77% 1-Year Est. Return

Fidelity Investments Boston, Massachusetts $2.3T AUM 54.33% 1-Year Est. Return

Jupiter Topco New York $245B AUM

APMC

Alta Partners Management Company Jackson, Wyoming $127M AUM 230.85% 1-Year Est. Return

Nextech Invest Zurich, Switzerland $2.11B AUM 413.84% 1-Year Est. Return

TCM

TCG Crossover Management Palo Alto, California $4.16B AUM 983.43% 1-Year Est. Return

BlackRock New York $6.73T AUM 46.02% 1-Year Est. Return

T. Rowe Price Associates Baltimore, Maryland $999B AUM 46.22% 1-Year Est. Return

State Street Boston, Massachusetts $3.37T AUM 44.26% 1-Year Est. Return

Commodore Capital New York $1.68B AUM 375.52% 1-Year Est. Return

Sio Capital Management's TYRA Position: Q2 2026 in Review

Sio Capital Management increased its Tyra Biosciences (TYRA) stake by 15% in Q2 2026, buying an estimated $2.97M and bringing the position to 695,315 shares worth $22.2M. The position accounts for 3.68% of the portfolio, ranked #7.

Sio Capital Management first reported a position in TYRA in Q1 2022 and has held it in 14 quarters since. The position peaked at $23.2M in Q1 2026. 169 funds tracked by Wall St. Rank hold TYRA as of Q2 2026.

Sio Capital Management held 695,315 shares of Tyra Biosciences worth $22.2M as of Q2 2026.
Sio Capital Management bought 89,876 Tyra Biosciences shares in Q2 2026, an estimated $2.97M.
Tyra Biosciences made up 3.68% of Sio Capital Management's portfolio in Q2 2026, its #7 holding.
Sio Capital Management first reported a position in Tyra Biosciences in Q1 2022 and has held it in 14 quarters since.
Sio Capital Management's Tyra Biosciences position peaked at $23.2M in Q1 2026.
169 funds tracked by Wall St. Rank held Tyra Biosciences as of Q2 2026.

Based on Sio Capital Management's 13F filing for Q2 2026, filed 14 Aug 2026.