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Tyra Biosciences
TYRA

Overview Fund Activity

121 hedge funds and large institutions have $542M invested in Tyra Biosciences in 2025 Q2 according to their latest regulatory filings, with 18 funds opening new positions, 61 increasing their positions, 21 reducing their positions, and 14 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
121
Holders Change
+4
Holders Change %
+3.42%
% of All Funds
1.62%
Holding in Top 10
3
Holding in Top 10 Change
-1
Holding in Top 10 Change %
-25%
% of All Funds
0.04%
New
18
Increased
61
Reduced
21
Closed
14
Calls
$1K
Puts
–
Net Calls
+$1K
Net Calls Change
-$182K

Top Buyers

1
CC
Commodore Capital
New York
$29.7M
2
RCM
RA Capital Management
Massachusetts
$117M
3
SCM
Sio Capital Management
New York
$7.75M
4
Balyasny Asset Management
Balyasny Asset Management
Illinois
$5.58M
5
Bank of America
Bank of America
North Carolina
$3.57M

Top Sellers

1
Fidelity Investments
Fidelity Investments
Massachusetts
$117K
2
O
OrbiMed
New York
$7.7M
3
CPX
Canaan Partners XI
California
$34.5M
4
Pictet Asset Management
Pictet Asset Management
Switzerland
$0
5
VPC
Vestal Point Capital
New York
$25.4M
Name Holding Trade Value Shares
Change 		Shares
Change %
RCM
1
RA Capital Management
Massachusetts
$117M +$14.9M +1,561,335 +15%
APMC
2
Alta Partners Management Company
Wyoming
$39M – – –
NI
3
Nextech Invest
Switzerland
$38.8M – – –
BI
4
BVF Inc
California
$37.7M – – –
CPX
5
Canaan Partners XI
California
$34.5M -$5.13M -536,481 -13%
CC
6
Commodore Capital
New York
$29.7M +$20.6M +2,150,000 +226%
TCM
7
TCG Crossover Management
California
$27.7M – – –
Janus Henderson Group
8
Janus Henderson Group
United Kingdom
$27.3M +$1.56M +163,053 +6%
VPC
9
Vestal Point Capital
New York
$25.4M -$2.15M -224,829 -8%
KCM
10
Kynam Capital Management
New Jersey
$22.3M -$728K -76,069 -3%
BlackRock
11
BlackRock
New York
$18.1M +$1.89M +197,411 +12%
Vanguard Group
12
Vanguard Group
Pennsylvania
$13.4M +$1.75M +183,322 +15%
FCM
13
Farallon Capital Management
California
$10.9M – – –
5VM
14
5AM Venture Management
California
$8.99M – – –
SCM
15
Sio Capital Management
New York
$7.75M +$3.77M +393,657 +94%
O
16
OrbiMed
New York
$7.7M -$9.07M -948,228 -54%
Balyasny Asset Management
17
Balyasny Asset Management
Illinois
$5.58M +$3.26M +340,142 +140%
Geode Capital Management
18
Geode Capital Management
Massachusetts
$5.43M +$487K +50,836 +10%
Marshall Wace
19
Marshall Wace
United Kingdom
$4.1M +$454K +47,408 +12%
State Street
20
State Street
Massachusetts
$4.01M +$47.8K +4,996 +1%
Millennium Management
21
Millennium Management
New York
$3.9M +$31.6K +3,299 +0.8%
Jacobs Levy Equity Management
22
Jacobs Levy Equity Management
New Jersey
$3.78M +$895K +93,498 +31%
Morgan Stanley
23
Morgan Stanley
New York
$3.62M +$1.89M +197,812 +110%
Bank of America
24
Bank of America
North Carolina
$3.57M +$2.77M +289,446 +347%
Walleye Capital
25
Walleye Capital
New York
$3.54M +$2.2M +229,666 +163%
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